{"id":"W2028305959","doi":"10.1016/j.biotechadv.2005.12.001","title":"Downstream processing of oncoretroviral and lentiviral gene therapy vectors","year":2006,"lang":"en","type":"review","venue":"Biotechnology Advances","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Genetic enhancement; Viral vector; Downstream (manufacturing); Computational biology; Downstream processing; Biology; Vector (molecular biology); Computer science; Gene; Biotechnology; Genetics; Recombinant DNA; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001883027,0.0004568576,0.0009796554,0.0002944821,0.00009514652,0.00001722181,0.0005104083,0.00112669,0.000005959792],"category_scores_gemma":[0.0000399352,0.0003686808,0.0002376236,0.000334756,0.0008936197,0.000008616258,0.0001901962,0.0003788362,0.000003711502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002836146,"about_ca_system_score_gemma":0.0002695821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001013031,"about_ca_topic_score_gemma":0.00005674171,"domain_scores_codex":[0.9980943,0.0001225813,0.0004705173,0.0007217174,0.0001717675,0.0004191105],"domain_scores_gemma":[0.9989126,0.00002282847,0.0004129166,0.0005511039,0.00005756853,0.00004301183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001198127,0.00006783264,0.00003882054,0.001201338,0.0000972461,0.000004647586,0.000002152218,8.579781e-7,0.01637019,0.00001291935,0.00005083656,0.9820334],"study_design_scores_gemma":[0.0003292184,0.002292531,0.000003216673,0.0004530613,0.0000531165,0.00003360668,0.000006284063,7.827784e-7,0.1655245,0.0000537659,0.8309169,0.0003330439],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01326726,0.9858244,0.00006340274,0.00002432874,0.00008856391,0.0004746941,0.0001043849,0.00004825815,0.0001047091],"genre_scores_gemma":[0.002735788,0.9959394,0.0005680681,0.00001224513,0.000171536,0.0000774283,0.0002836473,0.00006584852,0.0001460929],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9817003,"threshold_uncertainty_score":0.9998765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0239943609036002,"score_gpt":0.3393105268429528,"score_spread":0.3153161659393526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}