{"id":"W2028310816","doi":"10.1126/science.1150755","title":"Structure of a Site-2 Protease Family Intramembrane Metalloprotease","year":2007,"lang":"en","type":"article","venue":"Science","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":227,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Transmembrane domain; Transmembrane protein; Active site; Metalloproteinase; Protease; Protein structure; Chemistry; Biophysics; Integral membrane protein; Membrane protein; Biochemistry; Stereochemistry; Biology; Membrane; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001064703,0.0002898418,0.0003330863,0.0001299842,0.0003200452,0.0003929253,0.0004651608,0.0003428808,0.001183929],"category_scores_gemma":[0.0002501021,0.0001128989,0.0001292416,0.000206997,0.0002068214,0.0002456888,0.0001435863,0.0005325819,0.0003160242],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006262971,"about_ca_system_score_gemma":0.0005177383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002694821,"about_ca_topic_score_gemma":0.002056733,"domain_scores_codex":[0.9999545,0.000006327172,0.000001576361,0.000007522321,0.00002235587,0.000007750143],"domain_scores_gemma":[0.9999123,0.00001146597,0.0000212447,0.000003880416,0.00002151588,0.00002953908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001813554,0.0003018617,0.01121779,0.0005861287,0.0001043208,0.004621692,0.0005881743,0.008869558,0.9344529,0.004711247,0.00966134,0.02307154],"study_design_scores_gemma":[0.001547091,0.00296012,0.214172,0.0001972385,0.000328294,0.01219703,0.001691282,0.1905164,0.4294977,0.008747074,0.1378927,0.0002530108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875848,0.003748499,0.00328219,0.0006036105,0.000108533,0.00003429791,0.001088104,0.0001664741,0.003383578],"genre_scores_gemma":[0.9874578,0.001386368,0.004275473,0.0001338934,0.00004161558,0.00002123852,0.003692634,0.00002661206,0.002964369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002694821,"threshold_uncertainty_score":0.005358338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007661372818145961,"score_gpt":0.246739993521072,"score_spread":0.239078620702926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}