{"id":"W2028328484","doi":"10.1517/17460441.2014.962995","title":"The preclinical discovery of lofexidine for the treatment of opiate addiction","year":2014,"lang":"en","type":"article","venue":"Expert Opinion on Drug Discovery","topic":"Substance Abuse Treatment and Outcomes","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Opiate; Clinical trial; Addiction; Clonidine; Expert opinion; Detoxification (alternative medicine); Intensive care medicine; Pharmacology; Psychiatry; Alternative medicine; Anesthesia","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290783,0.0001989332,0.0004066211,0.00004389011,0.0001499605,0.00002655317,0.0001290819,0.0000571546,0.00001327792],"category_scores_gemma":[0.0001486326,0.00008741257,0.0004287317,0.00009765289,0.0001781854,0.0001850629,0.0000150843,0.00005303499,0.000005355324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008501016,"about_ca_system_score_gemma":0.00005938717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003638144,"about_ca_topic_score_gemma":0.00003200117,"domain_scores_codex":[0.9987406,0.00006855535,0.0004585948,0.0002437709,0.0002842679,0.0002041694],"domain_scores_gemma":[0.9965928,0.002475401,0.0002252493,0.0006110197,0.0000548237,0.00004069433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.04594938,0.01386538,0.09907395,0.0001697752,0.005889534,0.000004961756,0.0177425,0.0007907351,0.005570875,0.06309391,0.09604073,0.6518083],"study_design_scores_gemma":[0.02728326,0.01166928,0.07486664,0.001033867,0.0003570184,0.000008166365,0.004370564,0.003129985,0.1651749,0.0009138559,0.7106132,0.0005792939],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9402116,0.03761375,0.001913839,0.01077868,0.005216462,0.002940158,0.00006765024,0.00008121149,0.001176644],"genre_scores_gemma":[0.9633823,0.03086711,0.00007559182,0.0002302633,0.0007282703,0.00024964,0.0000811621,0.00002786649,0.0043578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.651229,"threshold_uncertainty_score":0.3564581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04310814663537015,"score_gpt":0.350976613227891,"score_spread":0.3078684665925208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}