{"id":"W2028368510","doi":"10.1111/j.1582-4934.2009.00851.x","title":"Membrane‐bound HSP70‐engineered myeloma cell‐derived exosomes stimulate more efficient CD8<sup>+</sup> CTL‐ and NK‐mediated antitumour immunity than exosomes released from heat‐shocked tumour cells expressing cytoplasmic HSP70","year":2009,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Microvesicles; Cytoplasm; CTL*; Cell biology; Cytotoxic T cell; CD8; Biology; Chemistry; Immune system; Immunology; Biochemistry; microRNA; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006043687,0.0007291231,0.001041631,0.00034575,0.0002638054,0.0001093643,0.0005205585,0.0004092989,0.00004540642],"category_scores_gemma":[0.0003203576,0.0006346075,0.0003076247,0.0002594618,0.0004775999,0.0000378198,0.0001730167,0.0006899324,0.000003314019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005166735,"about_ca_system_score_gemma":0.0002236915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004532786,"about_ca_topic_score_gemma":0.000001353164,"domain_scores_codex":[0.9961818,0.0004017926,0.00114369,0.0007026268,0.0008780023,0.000692115],"domain_scores_gemma":[0.9974505,0.0001205507,0.0005262604,0.0007202119,0.0003624238,0.0008200671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006691351,0.0003663461,0.0001810582,0.0001477111,0.000230459,0.00127928,0.0006660536,0.004201528,0.9917819,0.000005461327,0.0002167617,0.0002542275],"study_design_scores_gemma":[0.006307779,0.0009931716,0.00206761,0.000535784,0.0005493144,0.0001924978,0.001230025,0.009368967,0.9777333,0.00005365251,0.0003313583,0.0006365634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960942,0.03230861,0.0052632,0.0006711574,0.0001903591,0.0004264135,0.00004992394,0.00003412262,0.0001141711],"genre_scores_gemma":[0.9951158,0.001998237,0.001320548,0.0006911835,0.000440171,0.000004340382,0.0002609462,0.00009539423,0.0000734136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03417373,"threshold_uncertainty_score":0.9996105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726987842428434,"score_gpt":0.2210252334714784,"score_spread":0.21529824562905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}