{"id":"W2028368510","doi":"10.1111/j.1582-4934.2009.00851.x","title":"Membrane‐bound HSP70‐engineered myeloma cell‐derived exosomes stimulate more efficient CD8<sup>+</sup> CTL‐ and NK‐mediated antitumour immunity than exosomes released from heat‐shocked tumour cells expressing cytoplasmic HSP70","year":2009,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Microvesicles; Cytoplasm; CTL*; Cell biology; Cytotoxic T cell; CD8; Biology; Chemistry; Immune system; Immunology; Biochemistry; microRNA; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001173649,0.0003842646,0.0002371633,0.0001106038,0.00006246662,0.0002823989,0.00008657301,0.000238463,0.001223349],"category_scores_gemma":[0.00008914831,0.0000853033,0.0002816756,0.00009986592,0.000143289,0.000228914,0.0001888208,0.0006996248,0.0003456973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001340349,"about_ca_system_score_gemma":0.0001228385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001426138,"about_ca_topic_score_gemma":0.0001961069,"domain_scores_codex":[0.9998216,0.00002723565,0.00002680778,0.00003346205,0.0000367358,0.0000542119],"domain_scores_gemma":[0.9999082,0.00002302206,0.00002413329,0.00001246919,0.00001038625,0.0000218734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000105646,0.00005108253,0.00009751909,0.00002996448,0.000004499683,0.00002004257,0.000008713227,0.00004777918,0.9988056,0.00003479555,0.00002956712,0.0007647247],"study_design_scores_gemma":[0.00001786377,0.0004571152,0.002223874,0.000003757776,0.0000127797,0.0001112661,0.00001610622,0.0003673997,0.9957193,0.00002453883,0.001043877,0.000002289591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963769,0.0004429145,0.001916941,0.00005779248,0.00003804196,0.00002960375,0.00031196,0.00003727003,0.0007885443],"genre_scores_gemma":[0.9958823,0.0003183639,0.001206781,0.00005594341,0.00001803006,0.00003011334,0.0005591853,0.00001398089,0.00191538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223349,"threshold_uncertainty_score":0.004092515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726987842428434,"score_gpt":0.2210252334714784,"score_spread":0.21529824562905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}