{"id":"W20284704","doi":"10.1139/jpn.0421","title":"Implication of the hypothalamic–pituitary–adrenal axis in the physiopathology of depression","year":2004,"lang":"en","type":"article","venue":"Journal of Psychiatry and Neuroscience","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":413,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"","keywords":"Antidepressant; Endocrinology; Glucocorticoid receptor; Internal medicine; Depression (economics); Glucocorticoid; Hypothalamic–pituitary–adrenal axis; Psychology; Transgene; Pathophysiology; Medicine; Neuroscience; Biology; Hormone; Gene; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688185,0.00007419275,0.000134383,0.0000835119,0.0001038699,0.00001282714,0.0006184474,0.00002950687,0.000001604454],"category_scores_gemma":[0.0002161868,0.00003854267,0.00008366368,0.0004633012,0.0003247002,0.0001642871,0.00006471315,0.0002039381,1.674593e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005978185,"about_ca_system_score_gemma":0.0001132189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001118866,"about_ca_topic_score_gemma":0.000009226535,"domain_scores_codex":[0.9988416,0.0001584027,0.0003779028,0.0001626603,0.0003308656,0.0001285986],"domain_scores_gemma":[0.9991052,0.00009161353,0.0005114836,0.0002345728,0.00002909651,0.00002806282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008199716,0.0001766873,0.03408445,0.00001238712,2.57547e-7,0.000005773565,0.0001691102,0.000391137,0.9619772,0.001770837,0.000009633828,0.00132056],"study_design_scores_gemma":[0.0003548036,0.0002972636,0.7199637,0.00006709575,0.000005858281,0.000678276,0.0000706564,0.00003390298,0.274141,0.004333301,0.00001919838,0.00003495961],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968312,0.0002534551,0.0001650642,0.002032013,0.0005527256,0.00009024722,0.000003872303,0.000001496313,0.00006986334],"genre_scores_gemma":[0.9988723,0.0004184536,0.00008819931,0.0005720971,0.00003949274,0.000001478431,1.508127e-8,0.000003131516,0.000004795977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6878362,"threshold_uncertainty_score":0.1571724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976144500594667,"score_gpt":0.2795779485135638,"score_spread":0.2598165035076171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}