{"id":"W2028492419","doi":"10.1038/leu.2014.162","title":"Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling","year":2014,"lang":"en","type":"article","venue":"Leukemia","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; BC Cancer Agency","funders":"Deutsche Forschungsgemeinschaft","keywords":"IRF8; Biology; Myeloid; Retinoic acid; Myeloid leukemia; Cancer research; Immune system; Interferon regulatory factors; Tretinoin; Transcription factor; Cellular differentiation; Signal transduction; Myelopoiesis; Psychological repression; Immunology; Cell biology; Gene expression; Gene; Innate immune system; Haematopoiesis; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003474249,0.0003896202,0.0003957059,0.000454873,0.0002862476,0.0006140273,0.0005905472,0.0003376538,0.004163938],"category_scores_gemma":[0.0002641061,0.0002171619,0.0003416373,0.0002454111,0.000583306,0.0002474033,0.0003403815,0.001537169,0.001326725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007022544,"about_ca_system_score_gemma":0.0005300839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008409952,"about_ca_topic_score_gemma":0.001478546,"domain_scores_codex":[0.9995058,0.0001068177,0.00004864753,0.00006477729,0.0001091908,0.0001649106],"domain_scores_gemma":[0.9997248,0.00006957624,0.00004896617,0.0000694742,0.00001685356,0.00007031688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004329366,0.0001496494,0.0002651242,0.00002373537,0.000008070456,0.00004594877,0.00001895105,0.0001689582,0.9958053,0.0007736906,0.0002081311,0.002099517],"study_design_scores_gemma":[0.00003405474,0.0001346105,0.000757655,0.000002466423,0.000006404632,0.0001061647,0.00002411099,0.0006889303,0.9953316,0.00008617055,0.002824867,0.000002936956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892014,0.0007520323,0.003401186,0.0004394354,0.00007234156,0.00006568112,0.0008636936,0.0004885923,0.004715677],"genre_scores_gemma":[0.9935835,0.0002127827,0.002026462,0.00005603161,0.00001252282,0.00005761826,0.0006492371,0.00005391972,0.003347958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004163938,"threshold_uncertainty_score":0.01392978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006251910443762406,"score_gpt":0.2297657030987746,"score_spread":0.2235137926550121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}