{"id":"W2028513366","doi":"10.1146/annurev.pharmtox.47.120505.105230","title":"Intracellular Targets of Matrix Metalloproteinase-2 in Cardiac Disease: Rationale and Therapeutic Approaches","year":2006,"lang":"en","type":"review","venue":"The Annual Review of Pharmacology and Toxicology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":293,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Matrix metalloproteinase; Oxidative stress; Proteolysis; Extracellular matrix; Tissue inhibitor of metalloproteinase; Intracellular; Metalloproteinase; Endogeny; Pharmacology; Medicine; Matrix metalloproteinase inhibitor; Cell biology; Chemistry; Extracellular; Cancer research; Biology; Enzyme; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009389239,0.001122493,0.001592577,0.001844066,0.0003152619,0.001166553,0.001558095,0.00173799,0.002401506],"category_scores_gemma":[0.0005449295,0.0003320324,0.0004047818,0.001267607,0.00101832,0.001601836,0.0007722485,0.002723126,0.002577206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007432682,"about_ca_system_score_gemma":0.0008847117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003550622,"about_ca_topic_score_gemma":0.0006684287,"domain_scores_codex":[0.9997982,0.00004762222,0.00002705998,0.00003637961,0.00007121547,0.00001948132],"domain_scores_gemma":[0.9997759,0.00009219971,0.00002923688,0.00001288739,0.00006297123,0.00002685448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001794738,0.000280344,0.0002055001,0.00921687,0.00006893041,0.0009828965,0.0001085647,0.0006950076,0.009492814,0.020117,0.03609253,0.92256],"study_design_scores_gemma":[0.00008419262,0.0002982216,0.0005737505,0.002611089,0.00008742024,0.004246649,0.00008138956,0.0002553626,0.002250228,0.009722879,0.9797563,0.00003250735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001521798,0.9975318,0.0004608044,0.0006661068,0.0002809828,0.000007534471,0.000008928329,0.00001014183,0.0008815371],"genre_scores_gemma":[0.001117767,0.99661,0.0007488519,0.0003534016,0.0003751089,0.00002195718,0.00001965925,0.000002158091,0.0007509871],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002401506,"threshold_uncertainty_score":0.008033812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02609425346194741,"score_gpt":0.3215484745386142,"score_spread":0.2954542210766669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}