{"id":"W2028536981","doi":"10.1016/s0024-3205(01)01499-0","title":"Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse","year":2002,"lang":"en","type":"article","venue":"Life Sciences","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Hypericin; Hyperforin; Hypericum perforatum; CYP3A; CYP3A4; Pharmacology; Chemistry; CYP1A2; Gene isoform; Hydroxylation; Cytochrome P450; Demethylation; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003375549,0.0002302432,0.000247756,0.00003811756,0.0006084748,0.0001496864,0.0007068531,0.00005757923,0.0002885724],"category_scores_gemma":[0.00003055143,0.00005237919,0.00004909135,0.001201996,0.0003120262,0.00035359,0.00009668478,0.000153833,0.00005542581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005081644,"about_ca_system_score_gemma":0.00001265845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002178696,"about_ca_topic_score_gemma":0.003357083,"domain_scores_codex":[0.9983027,0.00009618493,0.0002195354,0.0004623319,0.000398291,0.0005209701],"domain_scores_gemma":[0.9993849,0.0003307065,0.00004739735,0.00008148091,0.00003003177,0.0001254368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000355655,0.001115842,0.6475875,0.00001130028,0.0001038844,0.0001517246,0.00580282,0.0001162156,0.08634131,0.0001032616,0.01242429,0.2458862],"study_design_scores_gemma":[0.0007732909,0.01103933,0.8889432,0.00004846056,0.00006001737,0.00009131299,0.01346057,0.0001836499,0.006694654,0.0000777738,0.0776272,0.00100057],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866443,0.0003408956,1.614088e-7,0.01056001,0.0001437965,0.0005107052,0.00001243517,0.00004211764,0.001745604],"genre_scores_gemma":[0.9959136,0.0001585501,0.0001062706,0.002316578,0.0002142491,0.0001022092,0.000002508599,0.000001039934,0.001184955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2448856,"threshold_uncertainty_score":0.4679957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08901870280997587,"score_gpt":0.2883223734430585,"score_spread":0.1993036706330826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}