{"id":"W2028546773","doi":"10.1038/mp.2015.23","title":"A novel Alzheimer disease locus located near the gene encoding tau protein","year":2015,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":309,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; McGill University and Génome Québec Innovation Centre; University of Toronto","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Alzheimer's Research Trust; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Synarc; Instituto de Salud Carlos III; Menzies Centre for Australian Studies, King's College London, University of London; University of California, Davis; National Institutes of Health; Bijzonder Onderzoeksfonds UGent; Instituut Born-Bunge; Centre for Medical Systems Biology; Hjartavernd; Marcus och Amalia Wallenbergs minnesfond; Elan; Junta de Andalucía; University of California, Irvine; Erasmus Medisch Centrum; University College London Hospitals NHS Foundation Trust; Mutuelle Générale de l'Education Nationale; Agence Française de Sécurité Sanitaire des Produits de Santé; Medical Research Council; Swedish Brain Power; Corporación Tecnológica de Andalucía; National Heart, Lung, and Blood Institute; Novartis; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; North Bristol NHS Trust; Dana Foundation; Vetenskapsrådet; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Fonds Wetenschappelijk Onderzoek; Alzheimer's Society; Stichting MS Research; Fondation pour la Recherche Médicale; Medpace; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Universitat de Barcelona; Academy of Finland; University of Cambridge; ZonMw; Newcastle University; National Eye Institute; Vlaamse regering; Alzheimer Society; Austrian Science Fund; National Institute for Health and Care Research; Centro de Biología Molecular Severo Ochoa; Universiteit Antwerpen; Northern California Institute for Research and Education; Medizinische Universität Graz; Fondation de France; University of Pennsylvania; U.S. Department of Veterans Affairs; National Institute on Deafness and Other Communication Disorders; Rush University; Stockholms Läns Landsting; University of Pittsburgh; Wellcome Trust; Johns Hopkins University; Pfizer; University of Washington; Emory University; York University; Vanderbilt University; Office of Research and Development; Belgian Federal Science Policy Office; Massachusetts General Hospital; GlaxoSmithKline; University of Miami; Northwestern University; Genentech; AstraZeneca; European Commission; National Institute of Environmental Health Sciences; School of Medicine, Boston University; Alzheimer's Association; Internationale Stichting Alzheimer Onderzoek; Sanofi; Eisai; University of Southern California; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Karl-Franzens-Universität Graz; Alfried Krupp von Bohlen und Halbach-Stiftung; Howard Hughes Medical Institute; Cardiff University; Hersenstichting; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Apolipoprotein E; Single-nucleotide polymorphism; Genome-wide association study; Dementia; SNP; Genotype; Locus (genetics); Alzheimer's disease; Genetics; Genetic association; Biology; Allele; Oncology; Disease; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002036061,0.0002711196,0.0002298508,0.00007331663,0.0002304158,0.0001044774,0.0002165641,0.00006591496,0.00006153154],"category_scores_gemma":[0.00007374573,0.0001829553,0.0002064102,0.0003843449,0.0002365797,0.00007290713,0.00009829693,0.0002862488,0.0003972517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006378906,"about_ca_system_score_gemma":0.001955545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001480587,"about_ca_topic_score_gemma":0.000006862495,"domain_scores_codex":[0.99793,0.00009098156,0.000240446,0.0004347623,0.0007693097,0.0005344684],"domain_scores_gemma":[0.9977591,0.000009707914,0.00007239196,0.0008047541,0.0001859111,0.001168144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03582395,0.05042121,0.4177449,0.001422571,0.1817,0.02912887,0.003643197,0.002189164,0.1228912,0.02688206,0.104488,0.02366489],"study_design_scores_gemma":[0.2147601,0.01511912,0.2864768,0.005711935,0.07468657,0.004739056,0.005932125,0.04014087,0.2318006,0.04590657,0.06203343,0.01269289],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8978017,0.07768418,0.002461071,0.01630514,0.0004127352,0.00295021,0.00006990494,0.0002212401,0.002093821],"genre_scores_gemma":[0.9947722,0.0000102186,0.003402119,0.001178777,0.0001802338,0.0002178836,0.0001123162,0.00006736916,0.00005886438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1789361,"threshold_uncertainty_score":0.7460702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03482563520159062,"score_gpt":0.3052607698054769,"score_spread":0.2704351346038863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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