{"id":"W2028546773","doi":"10.1038/mp.2015.23","title":"A novel Alzheimer disease locus located near the gene encoding tau protein","year":2015,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":309,"is_retracted":false,"has_abstract":false,"ca_institutions":"Occupational Cancer Research Centre; McGill University and Génome Québec Innovation Centre; University of Toronto","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; Alzheimer's Research Trust; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; National Human Genome Research Institute; National Institute of Mental Health; National Institute on Aging; Synarc; Instituto de Salud Carlos III; Menzies Centre for Australian Studies, King's College London, University of London; University of California, Davis; National Institutes of Health; Bijzonder Onderzoeksfonds UGent; Instituut Born-Bunge; Centre for Medical Systems Biology; Hjartavernd; Marcus och Amalia Wallenbergs minnesfond; Elan; Junta de Andalucía; University of California, Irvine; Erasmus Medisch Centrum; University College London Hospitals NHS Foundation Trust; Mutuelle Générale de l'Education Nationale; Agence Française de Sécurité Sanitaire des Produits de Santé; Medical Research Council; Swedish Brain Power; Corporación Tecnológica de Andalucía; National Heart, Lung, and Blood Institute; Novartis; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; North Bristol NHS Trust; Dana Foundation; Vetenskapsrådet; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Fonds Wetenschappelijk Onderzoek; Alzheimer's Society; Stichting MS Research; Fondation pour la Recherche Médicale; Medpace; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Universitat de Barcelona; Academy of Finland; University of Cambridge; ZonMw; Newcastle University; National Eye Institute; Vlaamse regering; Alzheimer Society; Austrian Science Fund; National Institute for Health and Care Research; Centro de Biología Molecular Severo Ochoa; Universiteit Antwerpen; Northern California Institute for Research and Education; Medizinische Universität Graz; Fondation de France; University of Pennsylvania; U.S. Department of Veterans Affairs; National Institute on Deafness and Other Communication Disorders; Rush University; Stockholms Läns Landsting; University of Pittsburgh; Wellcome Trust; Johns Hopkins University; Pfizer; University of Washington; Emory University; York University; Vanderbilt University; Office of Research and Development; Belgian Federal Science Policy Office; Massachusetts General Hospital; GlaxoSmithKline; University of Miami; Northwestern University; Genentech; AstraZeneca; European Commission; National Institute of Environmental Health Sciences; School of Medicine, Boston University; Alzheimer's Association; Internationale Stichting Alzheimer Onderzoek; Sanofi; Eisai; University of Southern California; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Karl-Franzens-Universität Graz; Alfried Krupp von Bohlen und Halbach-Stiftung; Howard Hughes Medical Institute; Cardiff University; Hersenstichting; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Apolipoprotein E; Single-nucleotide polymorphism; Genome-wide association study; Dementia; SNP; Genotype; Locus (genetics); Alzheimer's disease; Genetics; Genetic association; Biology; Allele; Oncology; Disease; Internal medicine; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542168,0.0006176196,0.0005835841,0.0009558749,0.0007806285,0.0007251671,0.000632632,0.001555786,0.003278502],"category_scores_gemma":[0.0006915999,0.0002094569,0.0007243027,0.0005673552,0.0005142174,0.0002283917,0.0002624482,0.0008927563,0.0007974328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003700947,"about_ca_system_score_gemma":0.0003244541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009925549,"about_ca_topic_score_gemma":0.0009224081,"domain_scores_codex":[0.9998426,0.00002119534,0.00001892018,0.00006092285,0.0000336453,0.00002259645],"domain_scores_gemma":[0.9994924,0.0001998783,0.0001197393,0.00003049401,0.00004219719,0.0001152695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003133871,0.0005942232,0.02899633,0.0002753774,0.0002637084,0.1764247,0.0009353945,0.0004834229,0.7635252,0.003214262,0.001280619,0.02087289],"study_design_scores_gemma":[0.001804193,0.00308935,0.3697799,0.0003461635,0.001102213,0.3729461,0.001164186,0.004551643,0.207353,0.0100422,0.02753223,0.0002889021],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928529,0.001485378,0.002335704,0.0006048856,0.000301989,0.00002406685,0.0004561215,0.00008074491,0.001858172],"genre_scores_gemma":[0.9943591,0.0004591883,0.002039479,0.0002291482,0.0001538731,0.00001615077,0.0005865834,0.00002120159,0.002135341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003278502,"threshold_uncertainty_score":0.01096767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03482563520159062,"score_gpt":0.3052607698054769,"score_spread":0.2704351346038863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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