{"id":"W2028552009","doi":"10.1002/jcb.22791","title":"Fibronectin inhibits osteoclastogenesis while enhancing osteoclast activity via nitric oxide and interleukin‐1β‐mediated signaling pathways","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Osteoclast; Osteopontin; Chemistry; Bone resorption; Fibronectin; Cell biology; Integrin; Vitronectin; RANK Ligand; Nitric oxide; Molecular biology; RANKL; Extracellular matrix; Endocrinology; Biochemistry; Biology; Cell; In vitro; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004415443,0.0003251725,0.0003882084,0.0001101138,0.0001243621,0.00007340599,0.0002629042,0.0003690106,0.00004359358],"category_scores_gemma":[0.0004332351,0.0003062707,0.0002476304,0.0001783637,0.0001368279,0.0000235179,0.0001927246,0.0004531431,0.000005649378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001965484,"about_ca_system_score_gemma":0.0002825938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001076958,"about_ca_topic_score_gemma":0.000008185814,"domain_scores_codex":[0.9983479,0.00007362756,0.0005283185,0.0003865532,0.0003102011,0.0003534033],"domain_scores_gemma":[0.9983652,0.00006411356,0.0005601834,0.0003534156,0.0002747481,0.0003823684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002477639,0.0001222161,0.0008645306,0.0001045974,0.00007078306,0.00003369588,0.00002437476,0.000006400962,0.9969181,0.000001025118,0.0001206039,0.001485946],"study_design_scores_gemma":[0.000903469,0.000122329,0.0007504543,0.00006332076,0.000103979,0.0002991393,0.0001248914,0.00001660817,0.9966785,0.00002102622,0.0005895732,0.0003266768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952244,0.002525089,0.001730208,0.0000364319,0.0002266388,0.00009133053,0.0000332367,0.00001354398,0.0001191203],"genre_scores_gemma":[0.9981064,0.00008079202,0.0007687079,0.00006739865,0.0007685256,0.000004315576,0.00004654831,0.0000446658,0.0001127056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002881939,"threshold_uncertainty_score":0.999939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005432945882162046,"score_gpt":0.1932409149415859,"score_spread":0.1878079690594238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}