{"id":"W2028552009","doi":"10.1002/jcb.22791","title":"Fibronectin inhibits osteoclastogenesis while enhancing osteoclast activity via nitric oxide and interleukin‐1β‐mediated signaling pathways","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Osteoclast; Osteopontin; Chemistry; Bone resorption; Fibronectin; Cell biology; Integrin; Vitronectin; RANK Ligand; Nitric oxide; Molecular biology; RANKL; Extracellular matrix; Endocrinology; Biochemistry; Biology; Cell; In vitro; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500855,0.0003950717,0.0002778799,0.0001780471,0.0001181671,0.0001796134,0.0001704702,0.000214073,0.0009503654],"category_scores_gemma":[0.00009999771,0.00009609719,0.0002743519,0.0001092122,0.0001918401,0.0001059185,0.0001208985,0.0005342339,0.0001366867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675335,"about_ca_system_score_gemma":0.0003700448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00146689,"about_ca_topic_score_gemma":0.003677742,"domain_scores_codex":[0.999811,0.00004058948,0.00001662019,0.0000196677,0.00005898023,0.00005320879],"domain_scores_gemma":[0.9999372,0.000009890817,0.00001512932,0.000003637785,0.00001076607,0.00002343702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008851861,0.0002522758,0.0002895398,0.0003197705,0.00002010884,0.00009038391,0.00001899595,0.0001282958,0.9910397,0.0001294053,0.0002564461,0.006569885],"study_design_scores_gemma":[0.0006639785,0.006129048,0.02074751,0.00009899096,0.0001611095,0.00082077,0.00008418377,0.002730627,0.9521613,0.0002566656,0.01611469,0.00003117308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668559,0.0229378,0.00277091,0.0004879834,0.0002720664,0.00008853382,0.0005634394,0.0001386615,0.005884823],"genre_scores_gemma":[0.9831208,0.00803714,0.003035947,0.0002317619,0.00007704653,0.0001355428,0.0006054959,0.00001001645,0.004746357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00146689,"threshold_uncertainty_score":0.003179312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005432945882162046,"score_gpt":0.1932409149415859,"score_spread":0.1878079690594238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}