{"id":"W2028578644","doi":"10.1007/s00018-014-1622-3","title":"Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia","year":2014,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Nanoparticles: synthesis and applications","field":"Materials Science","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Colloidal gold; Nucleolus; Hyperthermia; Biophysics; Cancer cell; Chemistry; Nanoparticle; Nucleus; Cell nucleus; Cell biology; Nanotechnology; Cancer; Biology; Materials science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006434797,0.0001735461,0.0002089467,0.00006305379,0.0002098758,0.0001917239,0.0004091091,0.00007380362,0.0003567438],"category_scores_gemma":[0.00002783535,0.0001431943,0.00003654892,0.0004674045,0.0003594203,0.0001868806,0.0001046092,0.0000784215,0.0001152016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001517345,"about_ca_system_score_gemma":0.00006369906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258594,"about_ca_topic_score_gemma":0.00003982222,"domain_scores_codex":[0.9983119,0.0001316011,0.0002596815,0.0005654207,0.0003096994,0.0004216752],"domain_scores_gemma":[0.9993224,0.00004452493,0.00008747855,0.0002952122,0.00004621238,0.0002041364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005944351,0.00007248369,0.0007048625,0.000009242411,0.000002495452,0.000001084551,0.0003431465,0.00003316954,0.995851,0.0007988666,0.001226389,0.0009513297],"study_design_scores_gemma":[0.000217615,0.00002650483,0.001026142,0.00002850427,0.00001416917,0.000001954194,0.0003005373,0.001536249,0.9908698,0.0003079572,0.005441376,0.0002292553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994327,0.0008263832,0.0001035918,0.003842539,0.00007877933,0.0001558878,0.00003277556,0.00004142214,0.0005915941],"genre_scores_gemma":[0.9978474,0.00009541735,0.0003458741,0.001561931,0.0000351754,0.00003148641,0.000001081946,0.00001975209,0.00006192382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00498125,"threshold_uncertainty_score":0.5839292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01125069081634747,"score_gpt":0.2268876275104401,"score_spread":0.2156369366940926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}