{"id":"W2028619564","doi":"10.1016/j.leukres.2010.01.006","title":"Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors","year":2010,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Terry Fox Research Institute","funders":"Cancer Research Society; Leukemia and Lymphoma Society","keywords":"Haematopoiesis; Myeloid leukemia; Cancer research; Progenitor cell; Fms-Like Tyrosine Kinase 3; Stem cell; Leukemia; Myeloid; Cytotoxic T cell; Bone marrow; Integrin-linked kinase; CD135; Tyrosine-kinase inhibitor; Tyrosine kinase; Medicine; Biology; Immunology; Kinase; Signal transduction; Cell biology; Internal medicine; Cancer; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002217122,0.0003361465,0.000505806,0.0002975423,0.0002458767,0.0008105004,0.0003548839,0.0005360906,0.001408721],"category_scores_gemma":[0.0001878064,0.000263507,0.0002929631,0.0002464043,0.0004385332,0.0003600281,0.0002863925,0.001087758,0.0003457362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000381037,"about_ca_system_score_gemma":0.0003387389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003868174,"about_ca_topic_score_gemma":0.0007414197,"domain_scores_codex":[0.999736,0.00003183054,0.00002116361,0.00004151042,0.00008893937,0.00008051541],"domain_scores_gemma":[0.9997856,0.00005390558,0.00005666204,0.00003496734,0.00001156473,0.00005740743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000365242,0.00008323578,0.0003925233,0.00003154848,0.00001852589,0.0001139189,0.00003390916,0.000375053,0.9940316,0.0009479973,0.0001515279,0.003454992],"study_design_scores_gemma":[0.00009795075,0.0008776038,0.004075187,0.000007287601,0.00005154435,0.0008354519,0.0000829744,0.002491401,0.9867317,0.0004307298,0.004310711,0.000007489535],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945487,0.001066183,0.002079575,0.0002109998,0.00004100463,0.00002412941,0.0001468542,0.0001172426,0.001765252],"genre_scores_gemma":[0.9970335,0.0003095461,0.000710729,0.00006190525,0.00001086674,0.00001744051,0.0002219741,0.00001911956,0.001615001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408721,"threshold_uncertainty_score":0.004712641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03293949577269067,"score_gpt":0.3241481324543699,"score_spread":0.2912086366816792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}