{"id":"W2028624362","doi":"10.1371/journal.pone.0102365","title":"Experimental Evolution of an Oncolytic Vesicular Stomatitis Virus with Increased Selectivity for p53-Deficient Cells","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Terry Fox Research Institute","keywords":"Oncolytic virus; Vesicular stomatitis virus; Biology; Virotherapy; Vesicular Stomatitis; Cancer cell; Virus; Virology; Cancer research; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003289826,0.0004982138,0.0003146989,0.0003024225,0.0001866264,0.0003345368,0.0004411375,0.0004561252,0.00070249],"category_scores_gemma":[0.0003252749,0.0001683908,0.0003876986,0.0001976752,0.0002526967,0.0001892502,0.0004247884,0.0008666146,0.0002201372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003174334,"about_ca_system_score_gemma":0.0001841716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000407482,"about_ca_topic_score_gemma":0.000444302,"domain_scores_codex":[0.9996697,0.00007177252,0.00004607019,0.00008176902,0.00008088871,0.00004982021],"domain_scores_gemma":[0.9997392,0.00007719618,0.00005981191,0.00005493478,0.00003305721,0.00003582551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006189748,0.0000351383,0.0001219642,0.00001841365,0.000005401753,0.00002665595,0.00001838714,0.0002262661,0.9984801,0.0001104028,0.00001621955,0.0008792026],"study_design_scores_gemma":[0.00001444492,0.0004169836,0.0007028588,0.000004170305,0.00001883887,0.0001527921,0.00000902838,0.001504441,0.9955587,0.00002761957,0.001583443,0.000006511556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848506,0.000474985,0.01280738,0.00004230565,0.00004131098,0.0002651636,0.0003276326,0.0001160909,0.001074609],"genre_scores_gemma":[0.9635665,0.0007246714,0.03031386,0.00005527262,0.00001497741,0.0004127598,0.001298045,0.0001146241,0.003499274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00070249,"threshold_uncertainty_score":0.002350092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729466216616406,"score_gpt":0.2569259182862456,"score_spread":0.2396312561200816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}