{"id":"W2028653361","doi":"10.1038/cgt.2011.14","title":"Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy","year":2011,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Terry Fox Foundation; National Cancer Institute; National Cancer Research Institute","keywords":"Cytosine deaminase; Oncolytic virus; Suicide gene; Prodrug; Vesicular stomatitis virus; Cancer cell; Chemistry; Biology; Pharmacology; Cancer research; Virology; Genetic enhancement; Virus; Cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003425177,0.0003791388,0.0003047405,0.00007916083,0.0001648952,0.00004184372,0.0004567391,0.0001900025,0.0002936404],"category_scores_gemma":[0.000008922982,0.0003211743,0.00009454981,0.000214843,0.0001705501,0.0000210285,0.00005689557,0.0002036243,0.00000956333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001092193,"about_ca_system_score_gemma":0.0007968315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008342579,"about_ca_topic_score_gemma":0.004640841,"domain_scores_codex":[0.9979337,0.0001831898,0.000224077,0.0007484049,0.0002392461,0.0006713581],"domain_scores_gemma":[0.998405,0.00001293301,0.0001354696,0.0009454145,0.0002103941,0.0002907908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01429389,0.0002507878,0.0004880637,0.00001016227,0.0001946294,0.00001585675,0.0001565841,0.00007585267,0.9247017,0.000001379029,0.00002392435,0.0597872],"study_design_scores_gemma":[0.002320028,0.01398779,0.00272175,0.00001217746,0.00001963848,0.00001806706,0.00005126201,0.0001358639,0.9799371,0.00002736598,0.0003221972,0.0004466967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931836,0.004164432,0.001639785,0.00004929828,0.00008986616,0.0005905699,0.00004632962,0.00004520741,0.000190957],"genre_scores_gemma":[0.9938954,0.002942174,0.001180744,0.0005435183,0.0005098505,0.000261214,0.00006740206,0.0001180646,0.0004816079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0593405,"threshold_uncertainty_score":0.999924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04878217427421708,"score_gpt":0.3291132861091766,"score_spread":0.2803311118349595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}