{"id":"W2028653361","doi":"10.1038/cgt.2011.14","title":"Enhancing VSV oncolytic activity with an improved cytosine deaminase suicide gene strategy","year":2011,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Terry Fox Foundation; National Cancer Institute; National Cancer Research Institute","keywords":"Cytosine deaminase; Oncolytic virus; Suicide gene; Prodrug; Vesicular stomatitis virus; Cancer cell; Chemistry; Biology; Pharmacology; Cancer research; Virology; Genetic enhancement; Virus; Cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002206838,0.0004927097,0.0004327243,0.0002626121,0.0001521197,0.0004659762,0.0003392525,0.0005298947,0.0004677501],"category_scores_gemma":[0.0002003433,0.0001510918,0.0003233899,0.0002147077,0.0003468936,0.0003262155,0.0002474119,0.0009427826,0.0002247039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007906549,"about_ca_system_score_gemma":0.000445647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143485,"about_ca_topic_score_gemma":0.001215596,"domain_scores_codex":[0.9998063,0.0000283307,0.00002186331,0.00003235418,0.000073424,0.00003776154],"domain_scores_gemma":[0.9999142,0.00001752722,0.00002098116,0.00001464183,0.00001927154,0.00001333247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004186087,0.00002436703,0.0000610989,0.00002474627,0.000006054435,0.00003073884,0.00001124315,0.0003015846,0.9962074,0.0006386226,0.00003771459,0.00261461],"study_design_scores_gemma":[0.000008820452,0.00006427205,0.0001543573,0.00000137494,0.000009544736,0.0001043401,0.000003669524,0.001332655,0.9969092,0.00005894684,0.001348853,0.000004046737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416725,0.001549456,0.05352149,0.0003543152,0.0001019868,0.0001208536,0.0002518208,0.0003014475,0.002126144],"genre_scores_gemma":[0.9748344,0.0007650835,0.02125948,0.00006585084,0.00001340405,0.00005591626,0.0002367471,0.00004078152,0.002728454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143485,"threshold_uncertainty_score":0.005736649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04878217427421708,"score_gpt":0.3291132861091766,"score_spread":0.2803311118349595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}