{"id":"W2028675119","doi":"10.1371/journal.pone.0060557","title":"Genomic Sequence and Virulence of Clonal Isolates of Vaccinia Virus Tiantan, the Chinese Smallpox Vaccine Strain","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Poxvirus research and outbreaks","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Nankai University; Directorate for Biological Sciences; State Key Laboratory of Infectious Disease Prevention and Control; National Institutes of Health; Health Canada; Centers for Disease Control and Prevention; National Natural Science Foundation of China","keywords":"ORFS; Vaccinia; Virulence; Virology; Biology; Smallpox vaccine; Genome; Virus; Smallpox virus; Genetics; Modified vaccinia Ankara; Attenuated vaccine; Whole genome sequencing; Variola virus; Gene; Open reading frame; Peptide sequence; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000122004,0.0002767277,0.0001460637,0.000450183,0.0001874562,0.0002222154,0.0001783164,0.0001723652,0.0002355965],"category_scores_gemma":[0.0003209463,0.00009546907,0.000292388,0.0004558375,0.0001739626,0.0001174455,0.0001471326,0.0002217811,0.0001104556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004814179,"about_ca_system_score_gemma":0.0003641197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007445747,"about_ca_topic_score_gemma":0.005603409,"domain_scores_codex":[0.9999007,0.000008486105,0.00001105991,0.00002638932,0.00002965424,0.00002368557],"domain_scores_gemma":[0.999859,0.00002921656,0.00003234901,0.00001869343,0.00002479066,0.00003595364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002413162,0.00004448618,0.02720784,0.00004089003,0.00002956094,0.0002120753,0.00029447,0.0001882583,0.9676793,0.0000962894,0.00004983742,0.00391568],"study_design_scores_gemma":[0.00004826844,0.00104921,0.8777066,0.00001775418,0.0001704954,0.001692952,0.000569474,0.001906224,0.1131824,0.0001010199,0.003531523,0.00002403712],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993647,0.00009326176,0.0001149332,0.000005828315,0.000002532167,0.00001150886,0.0002090741,0.000001988746,0.0001961979],"genre_scores_gemma":[0.9965752,0.0001189746,0.00041318,0.00001879623,0.000003919135,0.00001825487,0.002446448,0.000004059824,0.0004011281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007445747,"threshold_uncertainty_score":0.01480484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02619758682636759,"score_gpt":0.244492470888738,"score_spread":0.2182948840623704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}