{"id":"W2028680026","doi":"10.1073/pnas.0700007104","title":"Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agency for Science, Technology and Research; School of Medicine, New York University; National University of Singapore; York University","keywords":"Cycloheximide; Mitochondrion; Cytochrome c; Apoptosis; Cell biology; Biology; Proteasome; Bcl-2-associated X protein; Ubiquitin; Effector; Cytochrome; Mitochondrial apoptosis-induced channel; Molecular biology; Biochemistry; Programmed cell death; Protein biosynthesis; Caspase 3; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001545121,0.0002507518,0.000249505,0.0001119347,0.0001382458,0.0002829838,0.0001227118,0.0001372968,0.0007690496],"category_scores_gemma":[0.0001443032,0.0001016088,0.0001819206,0.0001041555,0.0001790421,0.0002635336,0.0001994654,0.0004368852,0.0003006341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000314292,"about_ca_system_score_gemma":0.000138153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543696,"about_ca_topic_score_gemma":0.0002545245,"domain_scores_codex":[0.9999022,0.00002057511,0.0000102043,0.00001688397,0.00002311162,0.00002696616],"domain_scores_gemma":[0.9998872,0.00002704822,0.00002517606,0.00001852369,0.00001438579,0.00002758123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007929826,0.00001683629,0.00007923136,0.00002076366,0.000002417212,0.00002771935,0.000005926432,0.00002160907,0.9990819,0.00005997289,0.00001096614,0.0005934375],"study_design_scores_gemma":[0.000008867157,0.0001179674,0.002362986,0.000002994991,0.000004861739,0.0001816751,0.00001028682,0.0003669962,0.9959756,0.00003563948,0.0009304718,0.000001689413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946931,0.00261725,0.002025779,0.00007021127,0.00001472903,0.00001065142,0.0000693571,0.00003159754,0.0004673089],"genre_scores_gemma":[0.9958437,0.001278208,0.001499228,0.00002402786,0.000008249044,0.00001584831,0.0002174324,0.00001094946,0.001102521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007690496,"threshold_uncertainty_score":0.002572715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01991955499557693,"score_gpt":0.2717888356021183,"score_spread":0.2518692806065413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}