{"id":"W2028709900","doi":"10.1074/jbc.m704616200","title":"Structure/Function Characterization of μ-Conotoxin KIIIA, an Analgesic, Nearly Irreversible Blocker of Mammalian Neuronal Sodium Channels","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Health and Medical Research Council; National Institute of General Medical Sciences; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Conotoxin; Sodium channel; Dorsal root ganglion; Sodium channel blocker; Chemistry; Tetrodotoxin; Analgesic; Pharmacology; IC50; Sodium; Patch clamp; Xenopus; Peptide; Biophysics; Biochemistry; Biology; Receptor; In vitro; Anatomy; Dorsum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004663663,0.0001863896,0.0003543455,0.00004348811,0.00003605738,0.000009919303,0.0002901866,0.0003556996,0.0001832065],"category_scores_gemma":[0.00012673,0.0001488118,0.0001949484,0.0001331674,0.0001465034,0.00001427342,0.00008430007,0.0002463121,6.848779e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002037166,"about_ca_system_score_gemma":0.00008072944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003522606,"about_ca_topic_score_gemma":0.000001020688,"domain_scores_codex":[0.9985179,0.00005764925,0.0007345597,0.0002421271,0.0002111867,0.0002365357],"domain_scores_gemma":[0.9985,0.00001866924,0.0007880104,0.0002154088,0.0003317068,0.0001461984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006910313,0.0002081976,0.0140521,0.00003022769,0.00007088194,0.000001344715,0.00002238984,0.00001128585,0.983755,0.000002849712,0.00004567312,0.001108994],"study_design_scores_gemma":[0.0007347316,0.00104004,0.03163937,0.0000154272,0.00003746639,0.00005530554,0.00007692588,0.00001008065,0.9650524,0.00002094866,0.001178321,0.0001389883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974456,0.00009052477,0.001938074,0.00004439616,0.0002674109,0.00008616823,0.00003880351,0.000004319209,0.00008472162],"genre_scores_gemma":[0.9983107,0.00005197001,0.0004990451,0.00006371689,0.000813049,6.325334e-7,0.0001345159,0.00001342769,0.0001129758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01870262,"threshold_uncertainty_score":0.6068368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272987149404576,"score_gpt":0.2462825754387838,"score_spread":0.2335527039447381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}