{"id":"W2028709900","doi":"10.1074/jbc.m704616200","title":"Structure/Function Characterization of μ-Conotoxin KIIIA, an Analgesic, Nearly Irreversible Blocker of Mammalian Neuronal Sodium Channels","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Health and Medical Research Council; National Institute of General Medical Sciences; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada","keywords":"Conotoxin; Sodium channel; Dorsal root ganglion; Sodium channel blocker; Chemistry; Tetrodotoxin; Analgesic; Pharmacology; IC50; Sodium; Patch clamp; Xenopus; Peptide; Biophysics; Biochemistry; Biology; Receptor; In vitro; Anatomy; Dorsum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008515651,0.0001913943,0.0001627754,0.0001014839,0.00009896654,0.0002047613,0.0002364372,0.0001908971,0.0008913025],"category_scores_gemma":[0.0001152792,0.00006081293,0.0001864439,0.000139293,0.00009665365,0.0001554075,0.00005857953,0.0003415242,0.0004070714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003593526,"about_ca_system_score_gemma":0.0002653474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303753,"about_ca_topic_score_gemma":0.0008183487,"domain_scores_codex":[0.9999593,0.000003075931,0.000003929931,0.000007626301,0.00001188779,0.00001414136],"domain_scores_gemma":[0.9999422,0.000006023834,0.00001692553,0.000004240905,0.00001225077,0.00001840328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007122501,0.0000246689,0.000183505,0.00002758147,0.000002879781,0.00004932836,0.000006839078,0.0001699171,0.9974217,0.00006392136,0.00001859856,0.001959861],"study_design_scores_gemma":[0.00002317449,0.0006446692,0.01125063,0.000009435749,0.00002164273,0.0004650152,0.00002108581,0.001220276,0.9824107,0.00005114099,0.003877027,0.000005184798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908205,0.00338129,0.002979549,0.00009683185,0.00001616988,0.00006744575,0.0005990608,0.00003398544,0.002005166],"genre_scores_gemma":[0.9861205,0.003474283,0.002896392,0.00008163055,0.00001118486,0.00003379576,0.002947518,0.00001165269,0.004422948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303753,"threshold_uncertainty_score":0.002981663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272987149404576,"score_gpt":0.2462825754387838,"score_spread":0.2335527039447381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}