{"id":"W2028714834","doi":"10.1517/14622416.6.3.293","title":"Polymorphisms of Genes Controlling Homocysteine Levels and IQ Score Following the Treatment for Childhood ALL","year":2005,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Dana-Farber Cancer Institute","keywords":"MTRR; Methylenetetrahydrofolate reductase; Cystathionine beta synthase; Homocysteine; Methionine synthase; Neurotoxicity; Homocystinuria; Internal medicine; Genotype; Medicine; Methyltransferase; Methionine; Genetics; Biology; Endocrinology; Bioinformatics; Oncology; Gene; Toxicity; Methylation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004900617,0.0004180876,0.0003492862,0.0003910796,0.0002554055,0.0004507491,0.0003483458,0.000341965,0.001885132],"category_scores_gemma":[0.002041511,0.0001107351,0.0005114292,0.0006496375,0.0002792868,0.0001384091,0.0002385003,0.0005702261,0.0001579252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000299221,"about_ca_system_score_gemma":0.0004728695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006441187,"about_ca_topic_score_gemma":0.002921941,"domain_scores_codex":[0.9996537,0.0001251951,0.00002630258,0.00008257486,0.0000699529,0.00004225987],"domain_scores_gemma":[0.9986732,0.0004148369,0.0005963051,0.00007284691,0.00008836689,0.0001544881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004960678,0.0000382055,0.9944624,0.00001533946,0.0002157838,0.0003492594,0.00006565126,0.0003452337,0.0009260722,0.00003489626,0.00007142979,0.002979621],"study_design_scores_gemma":[0.000006852515,0.0001337703,0.9981565,0.000008187609,0.0001287801,0.0005013744,0.00003952748,0.0005260829,0.0003190882,0.000055127,0.0001217616,0.000002925307],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989042,0.0003165242,0.000190591,0.00004875638,0.000006561849,0.000004046904,0.0002122159,0.000007186822,0.0003098316],"genre_scores_gemma":[0.999498,0.00007195331,0.0001037389,0.000007241526,0.000004166365,0.000002978141,0.0001651899,0.000002572631,0.0001442129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006441187,"threshold_uncertainty_score":0.01280737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07598469599941865,"score_gpt":0.35239318318584,"score_spread":0.2764084871864213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}