{"id":"W2028757382","doi":"10.1371/journal.pone.0059776","title":"A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hepatitis C virus research","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Greenberg Medical Research Institute; Novo Nordisk Fonden; Canada Excellence Research Chairs, Government of Canada; National Institute of Allergy and Infectious Diseases; Starr Foundation","keywords":"Virology; Glycoprotein; Genotype; Antibody; Hepatitis C virus; Virus; Neutralizing antibody; Hepacivirus; Biology; Immunology; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002539142,0.0004519879,0.001074995,0.0004677219,0.0002905081,0.0003054143,0.0003555563,0.0002776228,0.002252446],"category_scores_gemma":[0.0005378097,0.0004621587,0.0001218247,0.0006316807,0.0001457711,0.0005684412,0.0002990949,0.0008054117,0.001503615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003881601,"about_ca_system_score_gemma":0.0001665186,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1066035,"about_ca_topic_score_gemma":0.02672824,"domain_scores_codex":[0.9960968,0.0002058983,0.0009095669,0.000794173,0.0009164042,0.001077109],"domain_scores_gemma":[0.9979349,0.0001954238,0.0001926045,0.0007603188,0.0005258439,0.0003909601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001420926,0.00108046,0.4210266,0.0001534461,0.0002213423,0.0001295109,0.001061693,0.000004523878,0.5724858,0.000004573981,0.00007360593,0.003616318],"study_design_scores_gemma":[0.002671249,0.0005004354,0.7135825,0.001515581,0.00009238454,0.000002691658,0.0000390021,0.002096566,0.2786603,0.0001709694,0.0002344292,0.0004338974],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929841,0.001277405,0.0001774546,0.0009174125,0.00006219212,0.001919296,0.00008358676,0.0002426136,0.002336002],"genre_scores_gemma":[0.9859245,0.00207027,0.01013416,0.0006622222,0.0002746568,0.0001753121,0.0001414238,0.0001370254,0.0004803667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2938254,"threshold_uncertainty_score":0.999783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07430554953221793,"score_gpt":0.3037433994834174,"score_spread":0.2294378499511995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}