{"id":"W2028757382","doi":"10.1371/journal.pone.0059776","title":"A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hepatitis C virus research","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Greenberg Medical Research Institute; Novo Nordisk Fonden; Canada Excellence Research Chairs, Government of Canada; National Institute of Allergy and Infectious Diseases; Starr Foundation","keywords":"Virology; Glycoprotein; Genotype; Antibody; Hepatitis C virus; Virus; Neutralizing antibody; Hepacivirus; Biology; Immunology; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004140919,0.0004878385,0.000318818,0.0001264778,0.0001370651,0.0002307959,0.00007906224,0.0005809264,0.0007469876],"category_scores_gemma":[0.0002404791,0.0001422597,0.0001702517,0.00006904469,0.0001967713,0.0001708405,0.0001776519,0.0005300531,0.0001932091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009281238,"about_ca_system_score_gemma":0.0001187483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002104476,"about_ca_topic_score_gemma":0.0002698321,"domain_scores_codex":[0.9998143,0.00006004732,0.00001198843,0.00003567593,0.00003609182,0.00004184996],"domain_scores_gemma":[0.9998996,0.00003374807,0.0000173415,0.00001335103,0.00001688913,0.00001900706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004029204,0.00048541,0.001964013,0.00009866397,0.00001597034,0.00008822455,0.0000768036,0.0001572044,0.9906668,0.00007060912,0.0001158587,0.005857503],"study_design_scores_gemma":[0.0003634352,0.05234463,0.07737425,0.00008543464,0.0001242498,0.003294288,0.0002438863,0.002277321,0.8555452,0.0003743653,0.007947551,0.00002546547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972724,0.0008031789,0.001107448,0.00006803705,0.00002606126,0.00006160209,0.00005513883,0.00002165807,0.0005844574],"genre_scores_gemma":[0.9973783,0.0006180899,0.0007170522,0.0001900025,0.00002817654,0.00003236802,0.0001590848,0.000004515599,0.0008723825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007469876,"threshold_uncertainty_score":0.002498925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07430554953221793,"score_gpt":0.3037433994834174,"score_spread":0.2294378499511995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}