{"id":"W2028760429","doi":"10.1038/onc.2011.399","title":"The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Cisplatin; Biology; Cancer research; CHEK1; Ovarian cancer; Kinase; DNA damage; Phosphatase; G2-M DNA damage checkpoint; DNA-PKcs; Dephosphorylation; Cancer; Protein kinase A; Cell cycle; Cell cycle checkpoint; Phosphorylation; Cell biology; Chemotherapy; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001292083,0.0002805863,0.0002722039,0.0003547431,0.0002062147,0.0003235864,0.0002500439,0.0001986282,0.001338779],"category_scores_gemma":[0.0001743419,0.0002500961,0.0001887906,0.0002176843,0.0002790252,0.0002231405,0.0002745361,0.0006022115,0.0002435259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004993758,"about_ca_system_score_gemma":0.0003461577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007383621,"about_ca_topic_score_gemma":0.001274101,"domain_scores_codex":[0.9998732,0.00001695616,0.0000125076,0.00002114979,0.00003904785,0.00003708945],"domain_scores_gemma":[0.9999357,0.00001314906,0.00001453125,0.00001452021,0.000006677744,0.00001539497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002582204,0.0000528631,0.0003858916,0.00002992305,0.000007681143,0.00005789426,0.00001020317,0.0002275988,0.9962562,0.0002521647,0.0001188276,0.002342514],"study_design_scores_gemma":[0.00002541255,0.000194138,0.001730272,0.00000173123,0.00001057933,0.0001442036,0.00001128027,0.001139981,0.9952416,0.00005862787,0.001439841,0.00000238287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947587,0.001359469,0.001640396,0.0002565187,0.00006146961,0.00001966732,0.0002464447,0.0001292909,0.001528253],"genre_scores_gemma":[0.9971811,0.0004521495,0.0006828813,0.00002891894,0.000006272833,0.00001639907,0.0002411329,0.00001086881,0.001380338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001338779,"threshold_uncertainty_score":0.004478693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02066461491365505,"score_gpt":0.2346455085226263,"score_spread":0.2139808936089713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}