{"id":"W2028760429","doi":"10.1038/onc.2011.399","title":"The oncogenic phosphatase PPM1D confers cisplatin resistance in ovarian carcinoma cells by attenuating checkpoint kinase 1 and p53 activation","year":2011,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Cisplatin; Biology; Cancer research; CHEK1; Ovarian cancer; Kinase; DNA damage; Phosphatase; G2-M DNA damage checkpoint; DNA-PKcs; Dephosphorylation; Cancer; Protein kinase A; Cell cycle; Cell cycle checkpoint; Phosphorylation; Cell biology; Chemotherapy; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004658205,0.0002148109,0.0002662512,0.00007104013,0.0001536102,0.00002479691,0.0001113476,0.0001442232,0.00005532078],"category_scores_gemma":[0.0001563008,0.0001844574,0.00006979152,0.0002792953,0.0001216568,0.00007818953,0.00005918735,0.0003121968,0.00002466828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003091153,"about_ca_system_score_gemma":0.0002363224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006487378,"about_ca_topic_score_gemma":0.00048918,"domain_scores_codex":[0.9984434,0.00008529428,0.0004188833,0.0004125391,0.0002718241,0.0003680998],"domain_scores_gemma":[0.9989811,0.00009170129,0.0002060304,0.0004636012,0.00008478919,0.0001727477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000875938,0.0002450287,0.001098852,0.00005629777,0.00005705642,0.000168214,0.001283529,0.000001543652,0.9843931,0.000335659,0.002716502,0.008768279],"study_design_scores_gemma":[0.005761871,0.0001816654,0.003597139,0.0001796215,0.0000788836,0.00002002532,0.0003013402,0.0001795251,0.9799993,0.0001102878,0.009369933,0.0002204043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860032,0.005342207,0.0005262729,0.0006267889,0.0001833331,0.0007542642,0.00006653557,0.00003719545,0.006460249],"genre_scores_gemma":[0.9968401,0.0002265019,0.001793975,0.0003116112,0.00006065913,0.00005873758,0.00007880791,0.00004646401,0.0005831516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01083694,"threshold_uncertainty_score":0.7521954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02066461491365505,"score_gpt":0.2346455085226263,"score_spread":0.2139808936089713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}