{"id":"W2028785929","doi":"10.1038/ng.2682","title":"Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma","year":2013,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":835,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital; University of Toronto; SickKids Foundation; Hospital for Sick Children; McGill University and Génome Québec Innovation Centre; McGill University","funders":"Heidelberger Zentrum für Personalisierte Onkologie Deutsches Krebsforschungszentrum In Der Helmholtz-Gemeinschaft; National Cancer Institute; National Institutes of Health; Deutsche Krebshilfe; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Brain Tumour Charity; Bundesministerium für Bildung und Forschung; Canadian Institutes of Health Research; Genome Canada; Max-Planck-Gesellschaft; Genome British Columbia; Deutsches Krebsforschungszentrum","keywords":"Pilocytic astrocytoma; Biology; PTPN11; Cancer research; Astrocytoma; Glioma; Somatic cell; Fusion gene; MAPK/ERK pathway; Gene; Mutation; Genetics; Kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288453,0.0003169103,0.0002392223,0.001007417,0.0004170786,0.0006137932,0.0003854098,0.0007034825,0.001651986],"category_scores_gemma":[0.0008210983,0.0002007127,0.0003711124,0.000810383,0.0003631368,0.0002407721,0.0004225548,0.0002570841,0.0004438806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007608435,"about_ca_system_score_gemma":0.0003580666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003741016,"about_ca_topic_score_gemma":0.005819753,"domain_scores_codex":[0.9997076,0.00001998067,0.00003622939,0.00004266504,0.0001152486,0.00007824077],"domain_scores_gemma":[0.9997768,0.00003753602,0.00008387916,0.00002254517,0.00002770075,0.00005160086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001181738,0.00008999314,0.2428661,0.0001755909,0.000273881,0.2450743,0.0007077773,0.002563679,0.46352,0.001329038,0.001552563,0.04066545],"study_design_scores_gemma":[0.00006915371,0.0003041464,0.4993379,0.00003206416,0.0004780062,0.4090993,0.0007925697,0.004727509,0.07896898,0.001364055,0.004761182,0.00006517806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965605,0.0003525019,0.0003856397,0.0001351219,0.0000169453,0.00000928067,0.0001580763,0.00004563604,0.002336131],"genre_scores_gemma":[0.9995691,0.00005867869,0.0001382037,0.00001576984,0.000005411607,0.000001721202,0.00004730057,0.00000521376,0.0001586396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003741016,"threshold_uncertainty_score":0.007438481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00988872733113006,"score_gpt":0.2730605552671893,"score_spread":0.2631718279360593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}