{"id":"W2028868321","doi":"10.1021/jp403425z","title":"A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation","year":2013,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Department of Biochemistry, University of Cambridge; Gates Cambridge Trust; Fonds De La Recherche Scientifique - FNRS; Academia Sinica; Wellcome Trust; National Science Council; Medical Research Council; Cambridge Trust","keywords":"Lysozyme; Fibril; Chemistry; Biophysics; Cooperativity; Amyloid (mycology); Amyloid fibril; Protein structure; Helix (gastropod); Crystallography; Protein aggregation; Biochemistry; Amyloid β; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001895265,0.0003387648,0.0002881231,0.0001225646,0.0001087945,0.0001935818,0.0002768462,0.0003794761,0.000621506],"category_scores_gemma":[0.0002093263,0.0001032061,0.0002821317,0.00006332085,0.0002781235,0.0001484607,0.0001622316,0.000425662,0.0001426051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002267059,"about_ca_system_score_gemma":0.00008565388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003256891,"about_ca_topic_score_gemma":0.0003134395,"domain_scores_codex":[0.999803,0.00003905841,0.00001865125,0.00004097763,0.00005022566,0.00004816644],"domain_scores_gemma":[0.9998282,0.00006542378,0.00003332393,0.000021078,0.00001685793,0.00003511642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008179855,0.00003724346,0.00007141288,0.00001854046,0.000005547304,0.00002244401,0.000007380935,0.00002936427,0.9993814,0.00001669439,0.000009850603,0.0003182133],"study_design_scores_gemma":[0.00002029389,0.0005881452,0.001782552,0.000002122202,0.0000132553,0.0001116443,0.000005645556,0.0003236734,0.9967197,0.000008687139,0.0004216405,0.000002614778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981588,0.0005272534,0.0008778093,0.00003095057,0.00001242336,0.00001192934,0.00004010243,0.00002713363,0.0003137709],"genre_scores_gemma":[0.9986005,0.0001431458,0.000685677,0.00005941197,0.000008232044,0.00001626537,0.0001267949,0.000008667798,0.0003513321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000621506,"threshold_uncertainty_score":0.002079129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02072798216841759,"score_gpt":0.29315749418068,"score_spread":0.2724295120122624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}