{"id":"W2028878627","doi":"10.1038/ng.2455","title":"Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes","year":2012,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":435,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; ARID1A; Exome sequencing; Serous fluid; Somatic cell; Cancer research; Chromatin remodeling; Exome; Ubiquitin ligase; Endometrial cancer; Genetics; Epigenetics; Germline mutation; Gene; Mutation; Cancer; Ubiquitin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899339,0.000281042,0.0002267643,0.0007558384,0.0002202352,0.0004163879,0.0001718145,0.0004248456,0.001480986],"category_scores_gemma":[0.0005638185,0.0001396501,0.0003023034,0.0004947956,0.00016564,0.0001286308,0.0002897539,0.0002400809,0.0003021035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001910555,"about_ca_system_score_gemma":0.0001110313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008441818,"about_ca_topic_score_gemma":0.002218523,"domain_scores_codex":[0.9998584,0.00001150737,0.00001599652,0.00003345179,0.00005509617,0.00002565063],"domain_scores_gemma":[0.9997818,0.0000859182,0.00004217139,0.00003258799,0.00002266091,0.00003489605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009347887,0.00005144443,0.09090675,0.00009605879,0.0002132294,0.008338656,0.0002060367,0.0007424469,0.868276,0.0003619255,0.0008155382,0.02905717],"study_design_scores_gemma":[0.0001069007,0.0002710894,0.6298364,0.00004155352,0.0004635378,0.05075992,0.0003083932,0.006124359,0.3019151,0.0007662381,0.009376205,0.00003034547],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957687,0.0004158176,0.001533799,0.0001013617,0.00001187571,0.000008469352,0.001351873,0.00004910577,0.000758949],"genre_scores_gemma":[0.9958736,0.0002826003,0.001742458,0.00007536398,0.000007370518,0.000006428637,0.00113329,0.00001968274,0.0008592624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001480986,"threshold_uncertainty_score":0.004954398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02949744419691128,"score_gpt":0.3044910946347438,"score_spread":0.2749936504378325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}