{"id":"W2028889234","doi":"10.1016/j.ejca.2014.05.024","title":"Progression-free survival as an end-point in solid tumours – Perspectives from clinical trials and clinical practice","year":2014,"lang":"en","type":"review","venue":"European Journal of Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"","keywords":"Clinical trial; Clinical endpoint; Context (archaeology); Progression-free survival; Medicine; Clinical Practice; Surrogate endpoint; Intensive care medicine; End point; Endpoint Determination; Clinical study design; Overall survival; Oncology; Medical physics; Internal medicine; Family medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00563627,0.000969129,0.005894686,0.001748855,0.0002192651,0.00218755,0.001752718,0.001967192,0.002514748],"category_scores_gemma":[0.005807433,0.0004030541,0.001991089,0.002536299,0.0009354015,0.001838354,0.0008092167,0.003271524,0.0006343316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001196879,"about_ca_system_score_gemma":0.00212263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182435,"about_ca_topic_score_gemma":0.00299379,"domain_scores_codex":[0.9987186,0.0004837274,0.0002577443,0.0001752799,0.0003001078,0.00006451237],"domain_scores_gemma":[0.9931939,0.005495775,0.0006183201,0.00007600192,0.0004977214,0.0001183031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008128217,0.000112767,0.0004757729,0.08570223,0.001478589,0.0001144422,0.0000693539,0.0008068749,0.0006197821,0.004376083,0.01343451,0.8919967],"study_design_scores_gemma":[0.001139372,0.001485444,0.005034232,0.1140439,0.008346337,0.001623993,0.0003489617,0.001039655,0.0008044587,0.01316501,0.8528256,0.00014296],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006565326,0.9995075,0.00004373984,0.0002101047,0.00005160448,0.000003096162,0.000009353515,0.000001482928,0.0001073313],"genre_scores_gemma":[0.001459767,0.9977095,0.0002256613,0.0003677947,0.0001400304,0.0000112319,0.00002219644,0.000001598755,0.00006225912],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005894686,"threshold_uncertainty_score":0.02980781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1738267723523244,"score_gpt":0.59671152223017,"score_spread":0.4228847498778456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}