{"id":"W2028901643","doi":"10.1371/journal.pone.0103740","title":"Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":288,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Autism Research Institute","keywords":"Gene expression; Biology; Reporter gene; CREB; Regulation of gene expression; Cell biology; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001214667,0.000294249,0.000364218,0.0002679982,0.0002158426,0.0002815271,0.0002093696,0.0002781158,0.001459868],"category_scores_gemma":[0.0001117289,0.0001396459,0.0004736057,0.0002745981,0.000230889,0.0001898817,0.0001690171,0.0005402348,0.0003497327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140377,"about_ca_system_score_gemma":0.000214334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002516644,"about_ca_topic_score_gemma":0.004952042,"domain_scores_codex":[0.9998318,0.00001423909,0.00002282015,0.0000448905,0.0000436892,0.00004255481],"domain_scores_gemma":[0.9999207,0.00001824627,0.0000157382,0.00001007403,0.0000158789,0.00001937311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003213263,0.00004983069,0.0003464305,0.0000619537,0.000007379583,0.00004716359,0.00003373286,0.0000331429,0.9977329,0.00003430557,0.00004094823,0.001290753],"study_design_scores_gemma":[0.00003447909,0.0004227566,0.02099435,0.00001347869,0.00003497257,0.0001619174,0.0001235455,0.0008032452,0.9759957,0.00005227177,0.001354492,0.000008785651],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931386,0.002048735,0.002097215,0.0002172775,0.00004920744,0.0000236878,0.001219168,0.00005942257,0.001146639],"genre_scores_gemma":[0.9884743,0.002178852,0.003287347,0.00008675814,0.00001819105,0.00009036531,0.001456472,0.00001976515,0.004387988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002516644,"threshold_uncertainty_score":0.005003929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03401974689033349,"score_gpt":0.2533055549957468,"score_spread":0.2192858081054133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}