{"id":"W2028958622","doi":"10.1128/aac.05821-11","title":"<i>In Vitro</i> Resistance Profile of the Candidate HIV-1 Microbicide Drug Dapivirine","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Microbicide; Nevirapine; HIV drug resistance; Microbicides for sexually transmitted diseases; Drug resistance; Efavirenz; Context (archaeology); Vaginal microbicide; Reverse transcriptase; Virology; Reverse-transcriptase inhibitor; Lamivudine; Biology; Sexual transmission; Pharmacology; Medicine; Population; Viral load; Human immunodeficiency virus (HIV); Virus; Antiretroviral therapy; Microbiology; Genetics; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003251263,0.0002707622,0.000372799,0.0001933003,0.000164558,0.0004097676,0.0002893831,0.0003305366,0.002184433],"category_scores_gemma":[0.0005112216,0.0001584,0.0002813063,0.0002172921,0.0001210673,0.0001518719,0.000118443,0.0004762207,0.0006311345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977866,"about_ca_system_score_gemma":0.0002324454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004324261,"about_ca_topic_score_gemma":0.003537631,"domain_scores_codex":[0.9995987,0.0001886822,0.000041662,0.00004836573,0.00006731325,0.00005530963],"domain_scores_gemma":[0.9996226,0.0001563022,0.00004276162,0.0000384727,0.0001080532,0.00003180811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007192124,0.0002167615,0.002235125,0.0001790422,0.00002794264,0.0001279878,0.00007538888,0.00216429,0.9883615,0.0002107551,0.0009211843,0.004760718],"study_design_scores_gemma":[0.00003008951,0.003821126,0.01030087,0.00003124365,0.00004667537,0.0002860034,0.00009045358,0.004323564,0.9771099,0.00005487344,0.003886607,0.00001855692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864439,0.00377817,0.00150927,0.000205253,0.00005462424,0.0000595895,0.003013096,0.00005751307,0.004878638],"genre_scores_gemma":[0.9876897,0.001838608,0.003368119,0.0001393389,0.00003269575,0.00005399801,0.004229296,0.00001910987,0.002629034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004324261,"threshold_uncertainty_score":0.008598149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009384632928134108,"score_gpt":0.2208309755935202,"score_spread":0.2114463426653861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}