{"id":"W2028970780","doi":"10.1021/jm058271d","title":"Inhibition of Hepatitis B Virus (HBV) Replication by Pyrimidines Bearing an Acyclic Moiety:  Effect on Wild-Type and Mutant HBV","year":2006,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Hepatitis B virus; Chemistry; Moiety; Lamivudine; Pyrimidine; Virology; Mutant; Nucleoside; Nucleoside analogue; Stereochemistry; Virus; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099737,0.0002796575,0.0001969334,0.0001405222,0.00008115656,0.000103112,0.0001866538,0.0001729486,0.0008549779],"category_scores_gemma":[0.0001170899,0.00009624676,0.0001585964,0.0001251579,0.0001171305,0.0001138529,0.0001194162,0.0002177812,0.0001507865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000963171,"about_ca_system_score_gemma":0.00009960467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004020408,"about_ca_topic_score_gemma":0.0007047823,"domain_scores_codex":[0.9999362,0.00002009914,0.000007627696,0.00001027516,0.00001209188,0.00001376286],"domain_scores_gemma":[0.9999245,0.00002137678,0.00002051474,0.000006696974,0.000008096255,0.00001874743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006540651,0.0001006776,0.0001580872,0.0001960948,0.00001170954,0.00007436541,0.00002701337,0.000241611,0.9925528,0.00007092764,0.00004656608,0.005865957],"study_design_scores_gemma":[0.00008624868,0.007540842,0.003114675,0.00001784986,0.00004384723,0.0004335052,0.00001764781,0.0003380694,0.9851819,0.00002000342,0.003192401,0.00001301496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911284,0.007053997,0.0005399389,0.00002090966,0.00001589101,0.00002831058,0.0001436688,0.00003126908,0.001037556],"genre_scores_gemma":[0.992125,0.00522646,0.001209284,0.00002802684,0.00001816465,0.00001904253,0.0003122504,0.000006819154,0.00105497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008549779,"threshold_uncertainty_score":0.002860129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134006181857002,"score_gpt":0.2758059952968276,"score_spread":0.2644659334782576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}