{"id":"W2029013019","doi":"10.1042/bj20101346","title":"Characterization of the xenobiotic response of<i>Caenorhabditis elegans</i>to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites","year":2010,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Helminth infection and control","field":"Veterinary","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Pfizer","keywords":"Anthelmintic; Caenorhabditis elegans; Albendazole; Drug metabolism; Biology; Pharmacology; Xenobiotic; Drug; Nematode; Cytochrome P450; Metabolism; Gene; Biochemistry; Enzyme; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001882092,0.0001244291,0.0002491519,0.00007533433,0.0001626879,0.00005256236,0.0004034432,0.00006336939,0.00005735174],"category_scores_gemma":[0.001210364,0.0000630804,0.0001732491,0.0002476574,0.0003945372,0.00009491323,0.00009301909,0.0003628559,0.000004592509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000121634,"about_ca_system_score_gemma":0.00007226762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003773409,"about_ca_topic_score_gemma":0.000005861123,"domain_scores_codex":[0.9983231,0.0003442363,0.0007437712,0.0001404926,0.0002959699,0.0001524585],"domain_scores_gemma":[0.99818,0.0004590683,0.0006341885,0.0003945837,0.0002608631,0.00007134437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001003321,0.00009699841,0.0003800486,0.00001959598,0.00005010252,4.292881e-7,0.0009767771,9.706374e-7,0.9962025,0.0004918014,0.0001728107,0.000604662],"study_design_scores_gemma":[0.0009894534,0.00002745368,0.04955287,0.00005015184,0.0001008106,0.0002271629,0.000145293,0.0003322877,0.9465691,0.00007365986,0.001859773,0.00007191451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925975,0.0001218852,0.0006649916,0.005666521,0.0005272637,0.0003137772,0.00007958723,0.000007146662,0.00002128185],"genre_scores_gemma":[0.9993172,0.00003644739,0.00006347055,0.0002330892,0.0001942505,0.000009996132,0.000003144557,0.0000136471,0.000128754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04963331,"threshold_uncertainty_score":0.2572344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009252521556786087,"score_gpt":0.2536412198124355,"score_spread":0.2443886982556495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}