{"id":"W2029032030","doi":"10.1016/s1470-2045(14)71198-2","title":"Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): a randomised, controlled, open-label phase 2 trial","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":162,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Juravinski Cancer Centre; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Amgen","keywords":"Medicine; Panitumumab; Chemoradiotherapy; Internal medicine; Clinical endpoint; Head and neck squamous-cell carcinoma; Oncology; Cetuximab; Mucositis; Head and neck cancer; Radiation therapy; Surgery; Clinical trial; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006867216,0.0002694161,0.002225586,0.00004868797,0.00009396131,0.0000167295,0.0003531305,0.000101793,0.00001642482],"category_scores_gemma":[0.0002320902,0.0001072986,0.00003727748,0.0003030927,0.0004670342,0.00008369817,0.0001053421,0.0003399829,0.000001015555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002161521,"about_ca_system_score_gemma":0.00120518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003894076,"about_ca_topic_score_gemma":0.002675973,"domain_scores_codex":[0.9980648,0.0004193102,0.0004541237,0.0003302067,0.0003143605,0.0004171758],"domain_scores_gemma":[0.9983244,0.0004400104,0.000337346,0.0005026496,0.0002637288,0.0001318544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9447376,0.002333422,0.045614,0.00005978962,0.0001056337,0.00002829225,0.001894436,0.00000820186,0.0001597026,0.00001278004,0.0007404384,0.004305692],"study_design_scores_gemma":[0.9451519,0.04523449,0.005761895,0.0001344643,0.0001704545,0.00002611303,0.000399203,0.0002245249,0.0002475581,0.00001312619,0.002478129,0.0001581459],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860786,0.0009112945,0.00001928959,0.002291849,0.0001577354,0.007020294,0.00001600261,0.00001865829,0.003486271],"genre_scores_gemma":[0.9963778,0.00008226804,0.0005293346,0.001743131,0.0002021965,0.0006155454,0.00000519942,0.0000351924,0.0004093603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04290107,"threshold_uncertainty_score":0.4375509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07095194315395562,"score_gpt":0.3716621512149996,"score_spread":0.300710208061044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}