{"id":"W2029032030","doi":"10.1016/s1470-2045(14)71198-2","title":"Chemoradiotherapy with or without panitumumab in patients with unresected, locally advanced squamous-cell carcinoma of the head and neck (CONCERT-1): a randomised, controlled, open-label phase 2 trial","year":2015,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":162,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Juravinski Cancer Centre; Hôtel-Dieu de Québec; Centre hospitalier universitaire de Québec","funders":"Amgen","keywords":"Medicine; Panitumumab; Chemoradiotherapy; Internal medicine; Clinical endpoint; Head and neck squamous-cell carcinoma; Oncology; Cetuximab; Mucositis; Head and neck cancer; Radiation therapy; Surgery; Clinical trial; Cancer; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001312341,0.002032046,0.003150063,0.0004262877,0.0004392446,0.001045034,0.001093882,0.001828915,0.006919267],"category_scores_gemma":[0.001275767,0.0007574474,0.002852639,0.000512624,0.001339429,0.001246138,0.0004482705,0.003758498,0.001226192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001053017,"about_ca_system_score_gemma":0.001018569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002357533,"about_ca_topic_score_gemma":0.0058581,"domain_scores_codex":[0.9995489,0.0002003196,0.00002506677,0.0001110195,0.0000288193,0.00008589868],"domain_scores_gemma":[0.9994799,0.0001327159,0.000113266,0.00005776551,0.00003103327,0.0001852617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9692755,0.005463223,0.0007212525,0.00115908,0.001675639,0.0000439971,0.00009707238,0.0005589981,0.002709813,0.0001209646,0.001092932,0.01708156],"study_design_scores_gemma":[0.9390863,0.05727496,0.001712802,0.0000399917,0.000683721,0.00003132438,0.00004221175,0.0002400097,0.0002629992,0.00008387621,0.0005278215,0.0000140966],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855235,0.007709622,0.0003854601,0.0007513614,0.0007966817,0.001792113,0.0008255837,0.0001228707,0.002092919],"genre_scores_gemma":[0.9844824,0.005521739,0.0008797024,0.001123203,0.0004415961,0.001958348,0.001286666,0.00002993358,0.004276496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006919267,"threshold_uncertainty_score":0.02314723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07095194315395562,"score_gpt":0.3716621512149996,"score_spread":0.300710208061044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}