{"id":"W2029049247","doi":"10.1073/pnas.0805690105","title":"Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; McGill University Health Centre","funders":"","keywords":"Parathyroid hormone-related protein; Nuclear localization sequence; Biology; Receptor; Parathyroid hormone; NLS; Endocrinology; Nuclear protein; Internal medicine; Cell biology; Molecular biology; Cancer research; Transcription factor; Cytoplasm; Calcium; Gene; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009595757,0.00006894506,0.0001433327,0.0001173925,0.0001254344,0.000007819352,0.0001689228,0.00009223259,0.000002673328],"category_scores_gemma":[0.0006313377,0.00004531759,0.00002680271,0.0006660799,0.001116454,0.0002904775,0.00007118768,0.000187271,1.512173e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004135172,"about_ca_system_score_gemma":0.00004732435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008334455,"about_ca_topic_score_gemma":3.348493e-7,"domain_scores_codex":[0.99874,0.00001441621,0.0003143903,0.000185847,0.000657633,0.00008773679],"domain_scores_gemma":[0.9992931,0.00004410337,0.0003707597,0.000009173324,0.0002603489,0.00002254756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008518513,0.00004167407,0.06522243,0.0002761273,0.00002082427,1.676062e-7,0.002951839,0.0001002247,0.9147402,0.0160895,0.00004458609,0.0004272416],"study_design_scores_gemma":[0.001022029,0.0001924105,0.6262513,0.001009027,0.00003917216,0.000337554,0.0003826211,0.008105669,0.3435244,0.01896125,0.00003335356,0.0001412347],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964354,0.000184453,0.000001962728,0.002114893,0.0000058354,0.0003742616,0.00000406277,0.00000675817,0.000872364],"genre_scores_gemma":[0.999409,0.00007223193,0.0003777007,0.00009878966,0.0000108511,0.000004430943,1.790926e-7,0.00000421902,0.00002260059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5712157,"threshold_uncertainty_score":0.4113621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04188886099411564,"score_gpt":0.2782374480492171,"score_spread":0.2363485870551014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}