{"id":"W2029082826","doi":"10.1210/jc.2004-0893","title":"Nodal Induces Apoptosis and Inhibits Proliferation in Human Epithelial Ovarian Cancer Cells via Activin Receptor-Like Kinase 7","year":2004,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Sunnybrook Health Science Centre; University of Toronto; Women's College Hospital; York University","funders":"National Cancer Institute; York University","keywords":"XIAP; Activin receptor; Biology; Smad2 Protein; Activin type 2 receptors; ACVR2B; Endocrinology; Cancer research; Internal medicine; Apoptosis; NODAL; Nodal signaling; Molecular biology; Cell biology; Transforming growth factor beta; Transforming growth factor; TGF beta signaling pathway; Caspase; Programmed cell death; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009040518,0.0002081014,0.0005216414,0.0001044749,0.0001249209,0.00002228064,0.0003459605,0.0002343453,0.00002840906],"category_scores_gemma":[0.0003274451,0.0001498443,0.0001606752,0.00009807454,0.0003078646,0.00002230019,0.0001398592,0.0006161128,0.000004171867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002081989,"about_ca_system_score_gemma":0.0003056726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001222912,"about_ca_topic_score_gemma":0.00009375517,"domain_scores_codex":[0.9975007,0.0006272866,0.001069244,0.000262299,0.0002031128,0.0003374002],"domain_scores_gemma":[0.9986697,0.0001171047,0.0006456194,0.0002576601,0.0001589715,0.0001509527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006781183,0.0003290131,0.001533452,0.000009055689,0.0001449277,0.000006242218,0.0001525641,0.0004403588,0.9894047,0.00007478502,0.0001163224,0.0071104],"study_design_scores_gemma":[0.003530003,0.0003239074,0.02010829,0.0000405906,0.0001444385,0.00004220501,0.00004728199,0.000002386753,0.9703754,0.0004789086,0.00473787,0.000168763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948901,0.002383275,0.0002306162,0.001417318,0.0008600281,0.0001809285,0.00001163658,0.000006823554,0.00001928067],"genre_scores_gemma":[0.9953648,0.001582692,0.0005115052,0.000722061,0.001737161,0.00001215992,0.000006177878,0.00002360901,0.00003982668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0190294,"threshold_uncertainty_score":0.6110474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02602530309284242,"score_gpt":0.338549400199522,"score_spread":0.3125240971066796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}