{"id":"W2029090108","doi":"10.1073/pnas.0801585105","title":"ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Pyrimidine dimer; DNA damage; Nucleotide excision repair; DNA repair; Genome instability; Cell cycle; Biology; Molecular biology; Cell biology; CHEK1; Xeroderma pigmentosum; Cell cycle checkpoint; DNA; Chemistry; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499,0.0002991129,0.0003727781,0.0003186605,0.0001915993,0.0003568456,0.0001834154,0.000280114,0.002422184],"category_scores_gemma":[0.0001965646,0.0001632286,0.000267166,0.0002012431,0.0001492552,0.0001390782,0.0001769392,0.0003574017,0.001581254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897999,"about_ca_system_score_gemma":0.0002146926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003424834,"about_ca_topic_score_gemma":0.0003445481,"domain_scores_codex":[0.9998391,0.00002177166,0.00002534414,0.00005675138,0.00003139242,0.0000256799],"domain_scores_gemma":[0.9998327,0.00002907959,0.00004810072,0.00003804742,0.0000192532,0.00003258785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003216524,0.00003028368,0.001171437,0.00005944839,0.00001494076,0.000130397,0.00001530737,0.00008541657,0.9954548,0.00009749726,0.000120073,0.002498713],"study_design_scores_gemma":[0.00004314088,0.0003583578,0.02875309,0.00001348398,0.00004946183,0.001565812,0.00003958045,0.0007555892,0.9618405,0.0001147165,0.006457349,0.000008962972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815651,0.008166363,0.005018868,0.0002204586,0.00005140617,0.00005502043,0.002307077,0.0004090673,0.002206689],"genre_scores_gemma":[0.9919763,0.001872018,0.001979741,0.00007346755,0.00001492229,0.00005029992,0.002503816,0.00002610421,0.001503366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002422184,"threshold_uncertainty_score":0.008103013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03634334498884852,"score_gpt":0.3204045224564193,"score_spread":0.2840611774675708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}