{"id":"W2029091203","doi":"10.1073/pnas.0610902104","title":"Evidence for mutation showers","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute on Aging; National Institutes of Health","keywords":"Mutation; Mutant; Lac repressor; Genetics; Biology; Mutation rate; Mutation frequency; Context (archaeology); Mutagenesis; Molecular biology; Gene; Plasmid; lac operon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003248085,0.0004766851,0.0003302295,0.001039843,0.0002664187,0.0002828271,0.0003716054,0.0007347209,0.002538391],"category_scores_gemma":[0.0009461454,0.0002762748,0.0003008228,0.0003282827,0.0004394728,0.0002739457,0.0006763081,0.0006655481,0.0004381356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598074,"about_ca_system_score_gemma":0.0001503969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002408345,"about_ca_topic_score_gemma":0.0004394991,"domain_scores_codex":[0.9994414,0.00005759535,0.00005323444,0.0001973959,0.0001750379,0.00007528567],"domain_scores_gemma":[0.9981312,0.0004908114,0.0006882671,0.0001931323,0.0001516029,0.000345076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001279901,0.00002303455,0.01560676,0.00005495944,0.00003781679,0.0006434292,0.00006319221,0.00006964328,0.9792238,0.000272554,0.00007971706,0.003797119],"study_design_scores_gemma":[0.00003634718,0.001254279,0.3309836,0.00003637409,0.0001601531,0.02456599,0.0001618271,0.002008782,0.6340998,0.0007482434,0.005882626,0.0000619715],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912447,0.0004707702,0.006303123,0.00005157823,0.00001483126,0.00001866523,0.0003148904,0.0002294865,0.00135187],"genre_scores_gemma":[0.9937357,0.0002024309,0.0042625,0.00005329492,0.00000741363,0.00002191416,0.0004559445,0.00005075896,0.001209969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002538391,"threshold_uncertainty_score":0.008491755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06776918371669098,"score_gpt":0.3572513354780151,"score_spread":0.2894821517613241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}