{"id":"W2029117013","doi":"10.1002/jcb.21629","title":"Glycogen synthase kinase‐3beta suppresses tumor necrosis factor‐alpha expression in cardiomyocytes during lipopolysaccharide stimulation","year":2007,"lang":"en","type":"article","venue":"Journal of Cellular Biochemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"","keywords":"GSK-3; GSK3B; Tumor necrosis factor alpha; Glycogen synthase; Protein kinase B; Lipopolysaccharide; Stimulation; Signal transduction; Kinase; Phosphorylation; Biology; Chemistry; Molecular biology; Endocrinology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004620114,0.0002707332,0.0003174773,0.0001302583,0.00008472383,0.00005217327,0.0003563557,0.0002330374,0.00008793158],"category_scores_gemma":[0.0001792091,0.0002555461,0.0002277783,0.000130048,0.00006887034,0.00002037089,0.0001247074,0.0002447186,0.000002632045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349508,"about_ca_system_score_gemma":0.0002586527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001131015,"about_ca_topic_score_gemma":0.000002154095,"domain_scores_codex":[0.9981345,0.00003563498,0.0007102289,0.0003265972,0.0004061029,0.0003869174],"domain_scores_gemma":[0.9988232,0.00003075646,0.0004545953,0.0002933311,0.0002181797,0.0001799498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005077499,0.00008412616,0.01195622,0.00009904159,0.00006800771,0.0001615734,0.00006743131,0.0001681729,0.9863196,3.474492e-7,0.0002097113,0.000358004],"study_design_scores_gemma":[0.00109897,0.00006507062,0.002803299,0.0001988506,0.0000343713,0.00008054198,0.00009602577,0.000008041045,0.9947103,0.00001351584,0.0005868914,0.0003040844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941845,0.003705321,0.001566077,0.0000240059,0.0002759868,0.00009244925,0.00001394547,0.000009207432,0.0001285359],"genre_scores_gemma":[0.9976594,0.0001091679,0.001072057,0.00002966723,0.0006941868,0.00000393912,0.00004542435,0.00003650352,0.0003496009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009152917,"threshold_uncertainty_score":0.9999897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007948917112554089,"score_gpt":0.2401232600683397,"score_spread":0.2321743429557856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}