{"id":"W2029121478","doi":"10.1371/journal.pone.0085193","title":"δ-Opioid Receptor and Somatostatin Receptor-4 Heterodimerization: Possible Implications in Modulation of Pain Associated Signaling","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Somatostatin; Receptor; HEK 293 cells; Opioid; Somatostatin receptor; Signal transduction; μ-opioid receptor; Inhibitory postsynaptic potential; Pharmacology; Opioid receptor; Cell biology; Chemistry; Neuroscience; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325068,0.0002718787,0.0002081598,0.0001390512,0.0001368268,0.000282833,0.0002971754,0.0002620651,0.001264001],"category_scores_gemma":[0.00008320815,0.0001522303,0.0002160466,0.0000966932,0.0002227485,0.0002590925,0.0002569212,0.000344206,0.0002879817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294638,"about_ca_system_score_gemma":0.000163567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002572234,"about_ca_topic_score_gemma":0.0003422558,"domain_scores_codex":[0.9999043,0.00001718771,0.000008484971,0.00002295128,0.00002252961,0.00002458101],"domain_scores_gemma":[0.9999473,0.000005609641,0.00002054851,0.000004664396,0.000003958387,0.00001798468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005626932,0.00001238197,0.0003398635,0.00004133085,0.000007146559,0.000197465,0.0000105479,0.00004562242,0.9970511,0.0008149086,0.00004456069,0.001378779],"study_design_scores_gemma":[0.00005045614,0.000435173,0.02719835,0.00002522892,0.00007287272,0.003723321,0.0002045184,0.003464389,0.9494803,0.001109621,0.0142104,0.00002534975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711168,0.01011873,0.01283472,0.0005554838,0.0001297381,0.00003595788,0.0003058502,0.0001220127,0.004780591],"genre_scores_gemma":[0.9888017,0.003755518,0.00317205,0.0001158025,0.00002124035,0.00002852897,0.0002436818,0.00001748347,0.003844022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001264001,"threshold_uncertainty_score":0.004228532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789312106852757,"score_gpt":0.2149506954045914,"score_spread":0.1970575743360638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}