{"id":"W2029128580","doi":"10.1111/exd.12710","title":"Evidence that a neutrophil–keratinocyte crosstalk is an early target of <scp>IL</scp>‐17A inhibition in psoriasis","year":2015,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":202,"is_retracted":false,"has_abstract":true,"ca_institutions":"Barrie Urology Group; AV&R (Canada); Innovation Initiatives Ontario North; Moncton Hospital; Centre de Recherche Dermatologique du Québec Métropolitain; Innovaderm (Canada); Probity Medical Research","funders":"Cilag; LEO Pharma; AbbVie; Biogen Idec; Medac; Celgene; Novartis Pharma; Novartis; Novartis Institutes for BioMedical Research; Amgen; Pfizer; Kyowa Hakko Kirin; Eli Lilly and Company; Merck; GlaxoSmithKline","keywords":"Psoriasis; Secukinumab; CXCL1; Interleukin 17; Immunology; Medicine; Cytokine; Keratinocyte; Chemokine; Interleukin 8; Chemotaxis; CD11c; Internal medicine; Inflammation; Biology; Receptor; In vitro; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002744756,0.0001331711,0.0003048198,0.00009137045,0.0001002108,0.0002041768,0.00006684975,0.0001162394,0.001324053],"category_scores_gemma":[0.0001656935,0.00009221452,0.0001368764,0.00009758457,0.0001337441,0.00009606714,0.00008669238,0.0002875814,0.0001443633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008533299,"about_ca_system_score_gemma":0.0001211323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002341916,"about_ca_topic_score_gemma":0.000446612,"domain_scores_codex":[0.9998699,0.00005685324,0.000009259509,0.00001733276,0.000025761,0.00002083954],"domain_scores_gemma":[0.9998922,0.00002695252,0.00003107015,0.00001218461,0.00001159567,0.00002599903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006825912,0.0005531817,0.01696702,0.0001973926,0.0000683043,0.0002223018,0.00006787042,0.0002734158,0.9368058,0.00004805624,0.0001840318,0.03778675],"study_design_scores_gemma":[0.001989225,0.05419729,0.6368228,0.00005578451,0.0003419148,0.003445277,0.0001368812,0.001930618,0.2932337,0.000291282,0.007535765,0.00001940585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981087,0.00116027,0.0002062222,0.0000280591,0.000006133492,0.00002339934,0.00004122659,0.000007476325,0.0004183768],"genre_scores_gemma":[0.999323,0.0002887583,0.0001182915,0.00002397574,0.00001059785,0.00001370502,0.00004878459,0.000001588379,0.0001713476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324053,"threshold_uncertainty_score":0.0044294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05917956620733993,"score_gpt":0.2885891891835427,"score_spread":0.2294096229762028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}