{"id":"W2029132318","doi":"10.1097/nen.0000000000000011","title":"The Regulation of Reactive Changes Around Multiple Sclerosis Lesions by Phosphorylated Signal Transducer and Activator of Transcription","year":2013,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada","keywords":"STAT3; Multiple sclerosis; STAT protein; Phosphorylation; Microglia; Activator (genetics); Cancer research; Immunohistochemistry; Blot; Pathology; Western blot; Medicine; Biology; Inflammation; Immunology; Internal medicine; Cell biology; Receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001312255,0.0003386798,0.000184903,0.0005469512,0.0001752207,0.0002862921,0.0001174272,0.0002388185,0.001284858],"category_scores_gemma":[0.0002229437,0.0001344184,0.000183398,0.000257241,0.0002999567,0.0003326271,0.0002203417,0.0002899098,0.0003141039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504982,"about_ca_system_score_gemma":0.0001109073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003418699,"about_ca_topic_score_gemma":0.0003660732,"domain_scores_codex":[0.9999018,0.0000189661,0.00000925426,0.000021978,0.00002229548,0.00002566897],"domain_scores_gemma":[0.999866,0.00001512214,0.00007075709,0.000005089707,0.00002103793,0.00002185786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005367004,0.00003377277,0.004996059,0.0001142513,0.00001950519,0.0004023154,0.0001430263,0.00006365708,0.9873537,0.00011358,0.00009027983,0.006132974],"study_design_scores_gemma":[0.00009982556,0.001005406,0.4355896,0.00008971976,0.0001143881,0.004893315,0.0006791869,0.002268583,0.549359,0.001860812,0.004006066,0.00003423976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917976,0.004434776,0.002025046,0.00006668278,0.0000213503,0.00002317194,0.000214858,0.00006239238,0.001354145],"genre_scores_gemma":[0.9967649,0.001148004,0.001241343,0.00003575106,0.00002303653,0.00002238128,0.0001513564,0.000007573976,0.0006055895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284858,"threshold_uncertainty_score":0.004298329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03106782460857721,"score_gpt":0.2566161375499285,"score_spread":0.2255483129413512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}