{"id":"W2029132318","doi":"10.1097/nen.0000000000000011","title":"The Regulation of Reactive Changes Around Multiple Sclerosis Lesions by Phosphorylated Signal Transducer and Activator of Transcription","year":2013,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada","keywords":"STAT3; Multiple sclerosis; STAT protein; Phosphorylation; Microglia; Activator (genetics); Cancer research; Immunohistochemistry; Blot; Pathology; Western blot; Medicine; Biology; Inflammation; Immunology; Internal medicine; Cell biology; Receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001990637,0.000144868,0.0003903431,0.0001334863,0.000103837,0.000007660411,0.00008325748,0.000113332,0.00007587074],"category_scores_gemma":[0.00006673774,0.0001038615,0.0001306586,0.000104965,0.0003671815,0.0001756115,0.00001783488,0.0003754919,9.784832e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001796624,"about_ca_system_score_gemma":0.00002950193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003590743,"about_ca_topic_score_gemma":0.000002592585,"domain_scores_codex":[0.9986939,0.0002282245,0.0005649456,0.0001713543,0.0001651773,0.0001764214],"domain_scores_gemma":[0.9986485,0.0003518168,0.0005703756,0.0001298193,0.0002073655,0.00009216955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002003436,0.0004076736,0.001415448,0.000007271462,0.00004794813,0.00001532461,0.0006939026,0.000005254967,0.9938314,0.00001855842,0.0002291239,0.001324672],"study_design_scores_gemma":[0.001371393,0.005817788,0.1116655,0.00003017936,0.00006153365,0.001117133,0.0004762667,0.00009783204,0.8788775,0.0000202773,0.0004095414,0.00005510672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962209,0.0008194647,0.00009835722,0.002228968,0.0003125316,0.000265406,0.00001236881,0.000007939408,0.00003399361],"genre_scores_gemma":[0.9992796,0.0002069345,0.00006554381,0.0003431481,0.00005620202,0.000009205079,0.000003343057,0.00002190755,0.00001416967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1149539,"threshold_uncertainty_score":0.4235351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03106782460857721,"score_gpt":0.2566161375499285,"score_spread":0.2255483129413512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}