{"id":"W2029151927","doi":"10.1001/jama.2014.5985","title":"Association of Type and Location of<i>BRCA1</i>and<i>BRCA2</i>Mutations With Risk of Breast and Ovarian Cancer","year":2015,"lang":"en","type":"article","venue":"JAMA","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":509,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University; Université Laval; Centre hospitalier universitaire de Québec","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; School of Medicine; University of California, San Francisco; School of Medicine, Stanford University; Jonsson Comprehensive Cancer Center; National Institutes of Health; Pontificia Universidad Javeriana; Julius-Maximilians-Universität Würzburg; Universidad de Valladolid; Janssen Pharmaceuticals; Uppsala Universitet; Fondazione Italiana per la Ricerca sul Cancro; Università degli Studi di Torino; Sahlgrenska Universitetssjukhuset; Universität Regensburg; Medizinischen Hochschule Hannover; Universität zu Köln; Université Paris Descartes; Umeå Universitet; Deutsches Krebsforschungszentrum; Centre National de la Recherche Scientifique; Cancerfonden; Cedars-Sinai Medical Center; Institut National de la Santé et de la Recherche Médicale; Peter MacCallum Cancer Centre; National Breast Cancer Foundation; National Institute for Health and Care Research; University of Texas MD Anderson Cancer Center; Linköpings Universitet; University of Southern California; Beckman Research Institute, City of Hope; Cancer Research UK; Trinity College Dublin; Universitätsklinikum Köln; Cancer Association of South Africa; University of Pennsylvania; Amgen; University of Pretoria; Myriad Genetics; AstraZeneca; Lunds Universitet; U.S. Department of Defense; Breast Cancer Research Foundation; Huntsman Cancer Institute","keywords":"Ovarian cancer; Breast cancer; Medicine; Cancer; Oncology; Hazard ratio; Internal medicine; Mutation; Gynecology; Genetics; Confidence interval; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006679106,0.0001711043,0.0002065132,0.0004692942,0.0002011416,0.0003260796,0.0003125088,0.0002759913,0.001336036],"category_scores_gemma":[0.003905081,0.0002190227,0.0003852281,0.0005814498,0.0002585132,0.000242485,0.0002488249,0.0003562584,0.0001022666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176227,"about_ca_system_score_gemma":0.0002023935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00531404,"about_ca_topic_score_gemma":0.007956441,"domain_scores_codex":[0.9995709,0.0001249591,0.00004979306,0.0001175737,0.00007103189,0.00006572678],"domain_scores_gemma":[0.9966107,0.0008217154,0.001939832,0.0001998132,0.0001544077,0.000273497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003721987,0.000004655752,0.9995116,0.00000298137,0.00003497157,0.00001047052,0.000006580532,0.00001883533,0.00005370247,0.000005340581,0.00002823734,0.0002853699],"study_design_scores_gemma":[0.000003883364,0.00002927399,0.9994597,0.000004370771,0.00003485554,0.0001684082,0.00003638888,0.0001155453,0.00004591683,0.00001602127,0.0000840633,0.000001485101],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984568,0.0004679725,0.0001218706,0.0000433899,0.000004399758,0.000003798026,0.000565853,0.000002301862,0.0003336394],"genre_scores_gemma":[0.9991727,0.0001610834,0.0001109207,0.00001634872,0.000007481483,0.000003365377,0.0004310656,0.000001432892,0.00009557914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00531404,"threshold_uncertainty_score":0.01056623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00829802942289349,"score_gpt":0.2494021988386203,"score_spread":0.2411041694157268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}