{"id":"W2029194129","doi":"10.1038/sj.gt.3301274","title":"IL-12 plasmid-enhanced DNA vaccination against carcinoembryonic antigen (CEA) studied in immune-gene knockout mice","year":2000,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Perforin; CTL*; Biology; CD8; Cytotoxic T cell; Immune system; Immunology; Carcinoembryonic antigen; Antigen; Fas ligand; Cancer research; Cancer; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005544494,0.0004786278,0.0006699287,0.0003076766,0.0003948513,0.00002970026,0.0005699679,0.0004161406,0.002155327],"category_scores_gemma":[0.00002276284,0.0004488337,0.0002429816,0.0003972355,0.0001425023,0.0002052593,0.0000499574,0.0004401124,0.0008634839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001582008,"about_ca_system_score_gemma":0.0001700669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001631339,"about_ca_topic_score_gemma":0.00004685289,"domain_scores_codex":[0.9970087,0.0007181457,0.0007383474,0.0006014947,0.00008987511,0.0008434412],"domain_scores_gemma":[0.9988505,0.0001571082,0.0001946064,0.0006900739,0.00008185133,0.00002587285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00419199,0.0003077362,0.0003634956,0.000006092514,0.0003952801,0.00000755348,0.004173787,0.0001261916,0.8860136,0.00000664454,0.0002578684,0.1041498],"study_design_scores_gemma":[0.007033145,0.0004266539,0.1280196,0.00002650097,0.00001165377,0.00002407937,0.0003217732,0.000005385077,0.8281935,0.00003040144,0.03546295,0.000444327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9411438,0.05566362,0.00003305119,0.000209558,0.000851689,0.0007215334,0.00003783928,0.0001496588,0.001189326],"genre_scores_gemma":[0.9495652,0.04198957,0.00005471955,0.0007524658,0.00007073709,0.0001014155,0.0002332559,0.00007208181,0.007160592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1276561,"threshold_uncertainty_score":0.9999145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377738136950729,"score_gpt":0.2416745718222477,"score_spread":0.2278971904527405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}