{"id":"W2029215547","doi":"10.1542/peds.2010-3591","title":"Pediatric Analgesic Clinical Trial Designs, Measures, and Extrapolation: Report of an FDA Scientific Workshop","year":2012,"lang":"en","type":"article","venue":"PEDIATRICS","topic":"Pediatric Pain Management Techniques","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; SickKids Foundation; University of Toronto; Dalhousie University; BC Children's Hospital; Izaak Walton Killam Health Centre; McGill University; Hospital for Sick Children; University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","keywords":"Medicine; Analgesic; Clinical trial; Acetaminophen; Blinding; Placebo; Clinical study design; Randomized controlled trial; Intensive care medicine; Anesthesia; Alternative medicine; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.009408797,0.0002606078,0.0005940014,0.0008648317,0.0001576426,0.00006848006,0.0002286541,0.0003094204,0.0000409314],"category_scores_gemma":[0.003286326,0.0002514533,0.0001964228,0.001732207,0.0001919252,0.0005155751,0.0001325886,0.0004218431,0.00001040912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000644314,"about_ca_system_score_gemma":0.0003286036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001371506,"about_ca_topic_score_gemma":0.000003497097,"domain_scores_codex":[0.9961607,0.0003555385,0.001384956,0.0006044473,0.0009402808,0.0005540404],"domain_scores_gemma":[0.9968539,0.0006063514,0.0007131026,0.0009321679,0.0003174775,0.0005770281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001776633,0.001103544,0.9647874,0.0002401504,0.00003362692,0.00008852848,0.0001091423,6.510427e-7,0.0000269451,0.0001171387,0.01840597,0.01331024],"study_design_scores_gemma":[0.02472271,0.001546645,0.9500173,0.00002259978,0.003990592,0.0002914817,0.000155815,0.0002758737,0.0000590342,0.0007539171,0.0172919,0.0008721736],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779093,0.007164374,0.01050954,0.0001411565,0.001452317,0.001355578,0.000008045504,0.0002997623,0.001159976],"genre_scores_gemma":[0.9693424,0.002427862,0.0199148,0.00007186636,0.007623964,0.00004099001,0.00009037674,0.00004348327,0.000444324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02294608,"threshold_uncertainty_score":0.9999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1687835167386757,"score_gpt":0.403858388024923,"score_spread":0.2350748712862473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}