{"id":"W2029258726","doi":"10.1529/biophysj.108.138271","title":"Trans-Channel Interactions in Batrachotoxin-Modified Rat Skeletal Muscle Sodium Channels: Kinetic Analysis of Mutual Inhibition between μ-Conotoxin GIIIA Derivatives and Amine Blockers","year":2008,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; Nunavut Wildlife Research Trust; National Institutes of Health; University of Calgary","keywords":"Batrachotoxin; Sodium channel; Chemistry; Biophysics; Stereochemistry; Sodium; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003908217,0.0002903019,0.0004586912,0.0001495005,0.0002239361,0.000429151,0.000621399,0.0002768594,0.001270021],"category_scores_gemma":[0.0006615524,0.0002287909,0.000365066,0.0002426558,0.0003224168,0.0006466515,0.0002433999,0.0007751258,0.0003473985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007905283,"about_ca_system_score_gemma":0.0003109755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002114226,"about_ca_topic_score_gemma":0.002317513,"domain_scores_codex":[0.9996737,0.00004601944,0.00002170929,0.00006878936,0.0000997468,0.00008999357],"domain_scores_gemma":[0.9995497,0.0001851577,0.000103359,0.00004486851,0.0000611291,0.00005583198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000638803,0.00004392214,0.0004181427,0.00004891321,0.00003449676,0.00005128148,0.00006834541,0.0006637544,0.9961182,0.0004904835,0.00003660929,0.001386923],"study_design_scores_gemma":[0.00002024205,0.0002180836,0.003603501,0.000006578969,0.0000446813,0.0000954593,0.00005045938,0.01715281,0.9782993,0.00007532255,0.0004183066,0.00001528348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959831,0.0003959846,0.002679028,0.00002614003,0.000009652103,0.0000122691,0.00008066616,0.00003436665,0.00077883],"genre_scores_gemma":[0.9975588,0.0002675261,0.0009780173,0.00001180617,0.000003754854,0.00001774944,0.0001784096,0.00002734974,0.000956482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002114226,"threshold_uncertainty_score":0.005735636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299384066341073,"score_gpt":0.2612681921665601,"score_spread":0.2382743515031493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}