{"id":"W2029291154","doi":"10.1016/s1570-9639(02)00431-4","title":"Contribution of hydrophobic residues to ice binding by fish type III antifreeze protein","year":2002,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Antifreeze protein; Chemistry; Hydrophobic effect; Hydrogen bond; Antifreeze; Side chain; Alanine; Binding site; Globular protein; Crystallography; Biophysics; Stereochemistry; Biochemistry; Molecule; Amino acid; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635602,0.0002942195,0.0003532795,0.00004428877,0.0002161737,0.00005858084,0.0003360716,0.0001615839,0.0001831431],"category_scores_gemma":[0.00009959134,0.000235219,0.00008977701,0.0005738515,0.0003164755,0.000199431,0.0003342608,0.0002399623,0.00009382542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006372872,"about_ca_system_score_gemma":0.00001086611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002416792,"about_ca_topic_score_gemma":0.00001732889,"domain_scores_codex":[0.998208,0.00009355816,0.0003971655,0.0005891352,0.0002994478,0.000412618],"domain_scores_gemma":[0.9991482,0.00003957074,0.000231687,0.0003199624,0.00004506158,0.000215498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001357878,0.0002858755,0.00001045298,0.00002077912,0.00001861806,8.412113e-7,0.000127752,0.000002915962,0.997236,0.00006427876,0.001719704,0.0003770251],"study_design_scores_gemma":[0.0004179405,0.0006526635,0.001620457,0.00007174723,0.00001885745,0.000001687852,0.00001287895,0.0003153289,0.9950534,0.0005655691,0.0009189579,0.0003505654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945667,0.00002418905,0.00006759334,0.00270849,0.00002938096,0.001936181,0.0001916422,0.00006563929,0.0004101841],"genre_scores_gemma":[0.9956905,0.00008577183,0.003022536,0.0003704831,0.0000547841,0.000175406,0.00008334866,0.00002116549,0.0004959754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002954942,"threshold_uncertainty_score":0.9591954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413297174803125,"score_gpt":0.2177683245521455,"score_spread":0.2036353528041143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}