{"id":"W2029325974","doi":"10.1111/j.1600-0625.2009.00916.x","title":"Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component, TERC","year":2009,"lang":"en","type":"article","venue":"Experimental Dermatology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Telomerase; Dyskeratosis congenita; Telomerase reverse transcriptase; Telomere; Telomerase RNA component; Biology; Cancer research; Keratinocyte; Molecular biology; Cell biology; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001771078,0.0007182717,0.001564926,0.0002478978,0.0003287742,0.00002499539,0.0005339112,0.0003854033,0.0003276675],"category_scores_gemma":[0.0002822173,0.0003920907,0.0002934235,0.0009053708,0.0007656174,0.0004404951,0.0001215876,0.0005692984,0.000004497099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001755592,"about_ca_system_score_gemma":0.0002547747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004535105,"about_ca_topic_score_gemma":0.00003666534,"domain_scores_codex":[0.9951427,0.0009903318,0.001677299,0.0007668565,0.0007529049,0.0006699197],"domain_scores_gemma":[0.997025,0.0005445072,0.001079715,0.0009207409,0.00023064,0.0001994603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00626549,0.003070105,0.0096054,0.0002337174,0.0000804043,0.0001534327,0.01094768,0.000005005166,0.9580178,0.00001110218,0.01089098,0.0007188935],"study_design_scores_gemma":[0.006398013,0.0008077234,0.003075434,0.001012355,0.00009542508,0.0005164635,0.00810693,0.00005566062,0.9787636,0.00000999555,0.0007311776,0.0004272093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925642,0.003236101,0.00005928611,0.000644535,0.0002639258,0.002599093,0.0004079217,0.00006541018,0.0001595165],"genre_scores_gemma":[0.9967621,0.0004006315,0.0005625761,0.001557544,0.00004070306,0.0002371453,0.0002440909,0.00006189069,0.0001333113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02074583,"threshold_uncertainty_score":0.9998531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02929190512462596,"score_gpt":0.279534100279073,"score_spread":0.250242195154447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}