{"id":"W2029365012","doi":"10.3109/03602532.2012.754460","title":"Role of cytochrome P450–mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy","year":2013,"lang":"en","type":"review","venue":"Drug Metabolism Reviews","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Epoxide hydrolase 2; Arachidonic acid; Hydroxyeicosatetraenoic acid; Oxidative stress; Cytochrome P450; Signal transduction; Chemistry; Pathogenesis; STAT protein; Kinase; Biochemistry; Pharmacology; Extracellular; Intracellular; Enzyme; Biology; STAT3; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001637024,0.0007421979,0.005111314,0.0002697277,0.00004990346,0.0000176364,0.001130771,0.0004658565,0.0000880655],"category_scores_gemma":[0.0003282507,0.0004298073,0.001986387,0.00066354,0.0002013683,0.000009892686,0.0002787696,0.0004211047,0.00008102429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009572974,"about_ca_system_score_gemma":0.0002561619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004384753,"about_ca_topic_score_gemma":0.000005328918,"domain_scores_codex":[0.9936869,0.002807112,0.001990087,0.0007248347,0.0003083432,0.0004827772],"domain_scores_gemma":[0.9968536,0.0001375092,0.001373169,0.001338191,0.0001851617,0.000112395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008274462,0.0001665429,0.000005396087,0.003990019,0.0002947682,0.00000178011,0.00006010183,1.666663e-7,0.4056949,0.0001089513,0.001725061,0.587944],"study_design_scores_gemma":[0.0002055416,0.00003675419,0.0002099004,0.0006912574,0.00227226,0.00001702723,0.0000309467,9.126865e-7,0.003873164,0.00001998923,0.9922465,0.0003957607],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003741577,0.9928336,0.000001441733,0.00002238356,0.000238572,0.002504192,0.0004337856,0.000006425349,0.0002180641],"genre_scores_gemma":[0.000406169,0.9964707,0.0004403678,0.0002553162,0.0004481453,0.001043734,0.0007602094,0.00008129576,0.00009402621],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9905214,"threshold_uncertainty_score":0.9998153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0245440959750627,"score_gpt":0.2948070843540015,"score_spread":0.2702629883789389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}