{"id":"W2029367893","doi":"10.1016/j.molbiopara.2014.05.006","title":"A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum","year":2014,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Malaria Research and Control","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Plasmodium falciparum; Quinoline; Biology; Drug; Virology; Amino acid; Biochemistry; Stereochemistry; Combinatorial chemistry; Pharmacology; Malaria; Chemistry; Organic chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197042,0.0002055028,0.0002134048,0.000127789,0.0001493236,0.0001420845,0.0004015578,0.0003032115,0.001354774],"category_scores_gemma":[0.0001402095,0.000146366,0.0001423072,0.00008747471,0.0001493551,0.000142386,0.00011764,0.0002765653,0.0004317807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195551,"about_ca_system_score_gemma":0.0001389889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000832313,"about_ca_topic_score_gemma":0.001715355,"domain_scores_codex":[0.9999045,0.00002197043,0.000006691075,0.0000159634,0.00002531904,0.00002565583],"domain_scores_gemma":[0.9999363,0.00001546974,0.00001703963,0.000007458011,0.00000939987,0.00001427517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003479602,0.0000347027,0.0001862249,0.00004931665,0.000007824012,0.00008762163,0.00001297025,0.00008552612,0.997146,0.00006870185,0.0000749329,0.001898238],"study_design_scores_gemma":[0.0001339512,0.001031573,0.008056544,0.0000108734,0.00002526598,0.000715621,0.00002888092,0.001260237,0.9835865,0.00003724567,0.005103049,0.00001035404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897366,0.003846877,0.002897523,0.0001403202,0.00005783248,0.00005220739,0.0002214192,0.0001290064,0.002918205],"genre_scores_gemma":[0.9951698,0.0009503363,0.001891637,0.00006820544,0.00002507071,0.00002875545,0.0002773851,0.00001415092,0.001574773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354774,"threshold_uncertainty_score":0.004532218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007098261538654527,"score_gpt":0.2661052485105479,"score_spread":0.2590069869718934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}