{"id":"W2029367893","doi":"10.1016/j.molbiopara.2014.05.006","title":"A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum","year":2014,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Malaria Research and Control","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Plasmodium falciparum; Quinoline; Biology; Drug; Virology; Amino acid; Biochemistry; Stereochemistry; Combinatorial chemistry; Pharmacology; Malaria; Chemistry; Organic chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003457753,0.000453626,0.0009086747,0.0002989356,0.00006607376,0.0000305952,0.0001873876,0.000408082,0.00003873176],"category_scores_gemma":[0.0002379529,0.0003600333,0.0001090635,0.0003040085,0.0003692708,0.00008670318,0.00009346356,0.0008159048,0.00001569348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003568239,"about_ca_system_score_gemma":0.0001268444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008441537,"about_ca_topic_score_gemma":0.0001015968,"domain_scores_codex":[0.9971051,0.000197993,0.0005153921,0.000884233,0.0003937925,0.000903492],"domain_scores_gemma":[0.9986092,0.0001452753,0.0001034461,0.0003902064,0.0001369804,0.0006148352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0045308,0.0004216905,0.02741818,0.0003608563,0.0002136036,0.0007723857,0.0003465643,0.000004317426,0.9619252,0.00113995,0.0001614907,0.002704937],"study_design_scores_gemma":[0.01060708,0.001399288,0.04738797,0.0002985339,0.0002285938,0.001014259,0.0001024325,0.001342636,0.9356201,0.0004429879,0.0009139742,0.0006421374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988798,0.003381375,0.0007259796,0.005008711,0.00007474588,0.0006962365,0.00001336888,0.00006481,0.001236832],"genre_scores_gemma":[0.9975409,0.0001250113,0.0005639009,0.0013341,0.0001130287,0.00009734432,0.00007929956,0.00004555512,0.0001008907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02630512,"threshold_uncertainty_score":0.9998851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007098261538654527,"score_gpt":0.2661052485105479,"score_spread":0.2590069869718934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}