{"id":"W2029384396","doi":"10.1371/journal.pone.0007913","title":"Anthrax Lethal Toxin Induced Lysosomal Membrane Permeabilization and Cytosolic Cathepsin Release Is Nlrp1b/Nalp1b-Dependent","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; University of Toronto; American Heart Association; W. M. Keck Foundation","keywords":"Pyroptosis; Cell biology; Anthrax toxin; Programmed cell death; Cathepsin; Necroptosis; Cytosol; Biology; Cathepsin B; Endosome; Caspase 1; Cathepsin D; Apoptosis; Intracellular; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735936,0.0003154823,0.0002601544,0.0001655819,0.0001434625,0.000290308,0.0001237272,0.0002879208,0.002118649],"category_scores_gemma":[0.0001641376,0.0001226566,0.0002482694,0.0001331253,0.0003353342,0.0002437287,0.000254258,0.0005558138,0.000810563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003856031,"about_ca_system_score_gemma":0.0002391701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003325545,"about_ca_topic_score_gemma":0.000376876,"domain_scores_codex":[0.9997812,0.00003460922,0.00001848762,0.00004095481,0.00006559013,0.00005927744],"domain_scores_gemma":[0.9998134,0.00003167765,0.00006935146,0.00003217545,0.00001840846,0.0000351313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001216331,0.00002088823,0.00009549761,0.0000402064,0.000002454953,0.0001342026,0.000009138463,0.00002921802,0.9987348,0.0001073397,0.00005147668,0.0006531308],"study_design_scores_gemma":[0.00003306639,0.0002508076,0.00687032,0.000008300606,0.000005135344,0.001546373,0.00002611858,0.0004361659,0.9882691,0.0001199121,0.002428296,0.000006351126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861401,0.002645785,0.005546413,0.0003899828,0.00005521208,0.00005016988,0.000824275,0.0002332516,0.004114789],"genre_scores_gemma":[0.9935476,0.0006874509,0.001344063,0.00007685459,0.00001123259,0.0000357889,0.0009640042,0.00001912454,0.003313862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002118649,"threshold_uncertainty_score":0.007087588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0353417194707984,"score_gpt":0.2550639177071984,"score_spread":0.2197221982364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}