{"id":"W2029384396","doi":"10.1371/journal.pone.0007913","title":"Anthrax Lethal Toxin Induced Lysosomal Membrane Permeabilization and Cytosolic Cathepsin Release Is Nlrp1b/Nalp1b-Dependent","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; University of Toronto; American Heart Association; W. M. Keck Foundation","keywords":"Pyroptosis; Cell biology; Anthrax toxin; Programmed cell death; Cathepsin; Necroptosis; Cytosol; Biology; Cathepsin B; Endosome; Caspase 1; Cathepsin D; Apoptosis; Intracellular; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741136,0.000176704,0.0002192682,0.00005179387,0.0001254233,0.0000550725,0.0001519847,0.0002172386,0.0001995003],"category_scores_gemma":[0.0001946987,0.0001714381,0.00005115254,0.00009378095,0.00007086369,0.000009194394,0.00007273287,0.0001454657,0.000046775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002238536,"about_ca_system_score_gemma":0.00008288035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004935787,"about_ca_topic_score_gemma":0.00002038009,"domain_scores_codex":[0.9986136,0.00007736756,0.0002105414,0.0004433214,0.0003184257,0.0003367769],"domain_scores_gemma":[0.9992065,0.00001089554,0.0000565203,0.0003519483,0.0001873979,0.0001866902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002560322,0.0005831358,0.0005602138,0.00004377241,0.0000530361,0.000006844803,0.0001010936,9.139763e-7,0.9959129,0.00003061593,0.00008357016,0.002367855],"study_design_scores_gemma":[0.0008239256,0.0008441294,0.004199947,0.00003633892,0.00003660914,0.00001024173,0.00001859974,0.0002095247,0.9931752,0.00005288704,0.000362311,0.0002303012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966742,0.0003051473,0.00003614005,0.0006875855,0.00003653212,0.0002841333,0.0000370275,0.0000177527,0.001921523],"genre_scores_gemma":[0.9970841,0.0006903267,0.0002333907,0.0004286103,0.0004033194,0.00001388598,0.00008363365,0.00002306241,0.001039715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003639733,"threshold_uncertainty_score":0.6991041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0353417194707984,"score_gpt":0.2550639177071984,"score_spread":0.2197221982364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}