{"id":"W2029397995","doi":"10.1038/mt.2013.124","title":"Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":619,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Encana (Canada)","funders":"Alnylam Pharmaceuticals","keywords":"Biocompatibility; Tolerability; RNA interference; Nanotechnology; Chemistry; Pharmacology; Medicine; Materials science; RNA; Biochemistry; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003545088,0.0004477292,0.0001838659,0.0002601825,0.0001147615,0.0003097872,0.0001598746,0.0004124345,0.0009354772],"category_scores_gemma":[0.0002145712,0.0001675896,0.0002552974,0.0001159558,0.0001922695,0.0004385026,0.0003872259,0.0004699391,0.0007867725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003807436,"about_ca_system_score_gemma":0.0003994523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003324312,"about_ca_topic_score_gemma":0.0004894786,"domain_scores_codex":[0.9998268,0.00003220744,0.00001573172,0.00003242027,0.00006227402,0.00003059964],"domain_scores_gemma":[0.9999198,0.00001230384,0.00003310347,0.00000484837,0.00001861522,0.00001139013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006994019,0.00001645555,0.00003684826,0.0001262844,0.000004217623,0.00007752133,0.00002732797,0.0002755811,0.9909441,0.0008835447,0.0001250432,0.007413056],"study_design_scores_gemma":[0.00002036159,0.0002557766,0.0001399279,0.00001611405,0.00001190925,0.0001226072,0.00001233886,0.001079136,0.9855756,0.0001618075,0.01259426,0.00001031567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6912384,0.03322022,0.2484491,0.001556366,0.0006098516,0.0008015351,0.0007703316,0.001159096,0.02219505],"genre_scores_gemma":[0.9011126,0.01360356,0.07252142,0.0003774872,0.00006689561,0.0004618844,0.0003317565,0.0001131125,0.01141127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009354772,"threshold_uncertainty_score":0.003129423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185276471292557,"score_gpt":0.2448197405972732,"score_spread":0.2262920934680175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}