{"id":"W2029397995","doi":"10.1038/mt.2013.124","title":"Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics","year":2013,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":619,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Encana (Canada)","funders":"Alnylam Pharmaceuticals","keywords":"Biocompatibility; Tolerability; RNA interference; Nanotechnology; Chemistry; Pharmacology; Medicine; Materials science; RNA; Biochemistry; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793119,0.0002455236,0.0002631812,0.00008261809,0.00007731672,0.0000470844,0.0003449103,0.0001967146,0.00003675331],"category_scores_gemma":[0.00001474539,0.0002134274,0.0002323054,0.0001339862,0.0000839655,0.00001212365,0.00004283539,0.00006749976,0.00002452332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001395029,"about_ca_system_score_gemma":0.00007318825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008554842,"about_ca_topic_score_gemma":0.000002831238,"domain_scores_codex":[0.9986239,0.00008840537,0.0003784681,0.0003804242,0.0001544633,0.0003743529],"domain_scores_gemma":[0.9988506,0.00002268514,0.0001535953,0.0004945153,0.0004058839,0.00007269503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001987796,0.0001020193,0.0002079237,0.00003410024,0.0002293704,0.000001499244,0.00008300513,0.00006630509,0.9781452,0.00003467054,0.0005828864,0.02031419],"study_design_scores_gemma":[0.001060663,0.0009464632,0.0001165785,0.0000464536,0.00002853778,0.00001747872,0.0001884014,0.0003358283,0.9898371,0.0001032452,0.007058544,0.0002606723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849762,0.01035353,0.003590359,0.0002069415,0.0001613627,0.0006213132,0.00001211868,0.00002422321,0.00005389974],"genre_scores_gemma":[0.9945738,0.002781366,0.0008593758,0.001048888,0.0001199831,0.0001602155,0.00006836523,0.00004999733,0.0003379803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02005352,"threshold_uncertainty_score":0.8703318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185276471292557,"score_gpt":0.2448197405972732,"score_spread":0.2262920934680175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}