{"id":"W2029431187","doi":"10.1021/bi201118z","title":"Structural Insights into the Activation and Inhibition of Histo-Aspartic Protease from <i>Plasmodium falciparum</i>","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institutes of Health","keywords":"Chemistry; Zymogen; Aspartic acid; Stereochemistry; Proteases; Active site; Helix (gastropod); Histidine; Serine protease; Hydrogen bond; Protease inhibitor (pharmacology); Dimer; Protein structure; Enzyme; Protease; Biochemistry; Molecule; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005091743,0.00008050653,0.0001129995,0.00001777204,0.00005295367,0.000007127737,0.00004643247,0.00007446451,0.0001115224],"category_scores_gemma":[0.0001334552,0.00005282749,0.00003085217,0.00005684817,0.0001258022,0.00004767281,0.0000333322,0.0001260308,0.000002796754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003532783,"about_ca_system_score_gemma":0.00008738982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004784521,"about_ca_topic_score_gemma":0.000006533788,"domain_scores_codex":[0.999409,0.0000214812,0.0001360095,0.0001534286,0.0001720163,0.0001080914],"domain_scores_gemma":[0.99952,0.00002569888,0.00006634592,0.0002147633,0.00007457066,0.00009864681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005523111,0.00003543151,0.001294004,0.00007938901,0.00002835292,0.00000459038,0.0008586284,6.309089e-8,0.9956581,0.0001002809,0.0001793913,0.001209457],"study_design_scores_gemma":[0.0009733103,0.00007431005,0.01831006,0.0000582064,0.00003297142,0.000002504502,0.0001734959,0.0002863173,0.9789836,0.000980322,0.00006930964,0.00005556222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976235,0.0003222542,0.0000581335,0.0007010942,0.00001800958,0.0002709654,0.000004113429,0.00001476272,0.0009871781],"genre_scores_gemma":[0.9994107,0.000008617502,0.0001634088,0.00009882905,0.00008546084,0.00004242704,0.00003904965,0.000006231406,0.0001452785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01701605,"threshold_uncertainty_score":0.2154242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948914056688784,"score_gpt":0.2382118363300755,"score_spread":0.2187226957631877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}