{"id":"W2029431187","doi":"10.1021/bi201118z","title":"Structural Insights into the Activation and Inhibition of Histo-Aspartic Protease from <i>Plasmodium falciparum</i>","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institutes of Health","keywords":"Chemistry; Zymogen; Aspartic acid; Stereochemistry; Proteases; Active site; Helix (gastropod); Histidine; Serine protease; Hydrogen bond; Protease inhibitor (pharmacology); Dimer; Protein structure; Enzyme; Protease; Biochemistry; Molecule; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007781773,0.0003217281,0.0001905079,0.00005363691,0.000134317,0.0002724355,0.0004018003,0.0002981017,0.000932612],"category_scores_gemma":[0.00008957421,0.0001588981,0.0002425138,0.00006862504,0.0001888191,0.0002448766,0.0001166669,0.0007124874,0.0001979028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004194027,"about_ca_system_score_gemma":0.0003042685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001733159,"about_ca_topic_score_gemma":0.001476042,"domain_scores_codex":[0.9999537,0.000006122228,0.000001855674,0.000005714969,0.00002005648,0.0000124648],"domain_scores_gemma":[0.9999759,0.000005262337,0.000007980302,0.000001158556,0.000002493493,0.000007191473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005868081,0.0001923756,0.001362301,0.0003419433,0.000042019,0.001192459,0.0001308918,0.008419909,0.971193,0.004391758,0.001276339,0.01087009],"study_design_scores_gemma":[0.0006188372,0.002857155,0.03127604,0.0001434611,0.0002268898,0.004950799,0.0005890129,0.1178173,0.7877394,0.004074937,0.04961623,0.00008992782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822211,0.005312125,0.003932411,0.0007728786,0.0000675077,0.00003658636,0.0001656765,0.0001442168,0.007347408],"genre_scores_gemma":[0.9927579,0.002894717,0.002713747,0.0002110574,0.00001502497,0.00001041908,0.000306689,0.00001475952,0.00107559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001733159,"threshold_uncertainty_score":0.003446162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948914056688784,"score_gpt":0.2382118363300755,"score_spread":0.2187226957631877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}