{"id":"W2029480573","doi":"10.1186/s13058-014-0492-9","title":"Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers","year":2014,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Université Laval; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"Jonsson Comprehensive Cancer Center; European Regional Development Fund; Medical Research Council; Canadian Institutes of Health Research; lékařská fakulta Univerzity Karlovy; University of California, San Francisco; National Institutes of Health; National Cancer Institute; Liga Portuguesa Contra o Cancro; Ministero dello Sviluppo Economico; Radboud Universitair Medisch Centrum; Deutsche Krebshilfe; Universitair Medisch Centrum Groningen; University of Texas MD Anderson Cancer Center; Leids Universitair Medisch Centrum; Perelman School of Medicine, University of Pennsylvania; Associazione Italiana per la Ricerca sul Cancro; National Health and Medical Research Council; Jewish General Hospital; KWF Kankerbestrijding; State Education Development Agency Republic of Latvia; Lietuvos Mokslo Taryba; Israel Cancer Association; Odense Universitetshospital; Ovarian Cancer Research Fund; Landspítali Háskólasjúkrahús; Susan G. Komen; Hungarian Scientific Research Fund; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Generalitat de Catalunya; Russian Foundation for Basic Research; Beth Israel Deaconess Medical Center; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; NIH Office of the Director; Ministério da Ciência, Tecnologia e Inovação; Universiteit Leiden; Istituto Toscano Tumori; Cancer Association of South Africa; National Breast Cancer Foundation; National Institute for Health and Care Research; Institut Català de la Salut; University of Pennsylvania; Radboud Universiteit; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Breast Cancer Research Foundation; McGill University; Univerzita Karlova v Praze; Clalit Health Services; Deutsches Krebsforschungszentrum; Peter MacCallum Cancer Centre; Helsingin ja Uudenmaan Sairaanhoitopiiri; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancer Center, University of Kansas; Cancerfonden; Canadian Breast Cancer Research Alliance; European Commission; Istituto Oncologico Veneto; Royal Marsden NHS Foundation Trust; Helsingin Yliopisto; Memorial Sloan-Kettering Cancer Center; Génome Québec; Dr. Ralph and Marian Falk Medical Research Trust; Kansas Bioscience Authority; European Social Fund; University of Chicago; Instituto de Salud Carlos III; Ohio State University; Cancer Australia; U.S. Department of Defense; Cancer Research UK; University of Southern California","keywords":"Breast cancer; Surgical oncology; Medicine; Allele; Oncology; Mutation; BRCA2 Protein; Internal medicine; Genetics; Cancer; Germline mutation; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007439549,0.0002834731,0.0003191132,0.001049158,0.0002419118,0.0003894434,0.0002447653,0.0003361806,0.00249948],"category_scores_gemma":[0.002447342,0.0001757861,0.0003569433,0.0008087584,0.0002337633,0.0001790876,0.000286309,0.000252623,0.000152157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001529991,"about_ca_system_score_gemma":0.000160157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003191166,"about_ca_topic_score_gemma":0.002604315,"domain_scores_codex":[0.9996064,0.00008668726,0.00003726005,0.0001545217,0.00005935951,0.00005572419],"domain_scores_gemma":[0.9978939,0.0008144295,0.0007910429,0.0001837316,0.00009815246,0.0002188039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001780391,0.000009266339,0.9974461,0.000007115149,0.00009164449,0.00007059661,0.00003922472,0.00006888539,0.0005852199,0.00001598651,0.00003444773,0.001453441],"study_design_scores_gemma":[0.000005282338,0.00003452845,0.9992073,0.000002870613,0.00005339579,0.0002887411,0.00002828299,0.0001217346,0.0001171445,0.00003176717,0.0001068383,0.000002168066],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991974,0.0002411304,0.00008989829,0.00001267495,0.000001491191,0.000002646777,0.0002544689,0.000003190175,0.0001969613],"genre_scores_gemma":[0.9993656,0.00007638906,0.0001211898,0.000007172137,0.000004898264,0.000003901451,0.000299416,0.000003021946,0.0001183266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003191166,"threshold_uncertainty_score":0.008361638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042418714421266,"score_gpt":0.3444474156572364,"score_spread":0.3240232285130237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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