{"id":"W2029480573","doi":"10.1186/s13058-014-0492-9","title":"Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers","year":2014,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; Université Laval; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; University Health Network","funders":"Jonsson Comprehensive Cancer Center; European Regional Development Fund; Medical Research Council; Canadian Institutes of Health Research; lékařská fakulta Univerzity Karlovy; University of California, San Francisco; National Institutes of Health; National Cancer Institute; Liga Portuguesa Contra o Cancro; Ministero dello Sviluppo Economico; Radboud Universitair Medisch Centrum; Deutsche Krebshilfe; Universitair Medisch Centrum Groningen; University of Texas MD Anderson Cancer Center; Leids Universitair Medisch Centrum; Perelman School of Medicine, University of Pennsylvania; Associazione Italiana per la Ricerca sul Cancro; National Health and Medical Research Council; Jewish General Hospital; KWF Kankerbestrijding; State Education Development Agency Republic of Latvia; Lietuvos Mokslo Taryba; Israel Cancer Association; Odense Universitetshospital; Ovarian Cancer Research Fund; Landspítali Háskólasjúkrahús; Susan G. Komen; Hungarian Scientific Research Fund; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Generalitat de Catalunya; Russian Foundation for Basic Research; Beth Israel Deaconess Medical Center; Erasmus Medisch Centrum; Vrije Universiteit Amsterdam; NIH Office of the Director; Ministério da Ciência, Tecnologia e Inovação; Universiteit Leiden; Istituto Toscano Tumori; Cancer Association of South Africa; National Breast Cancer Foundation; National Institute for Health and Care Research; Institut Català de la Salut; University of Pennsylvania; Radboud Universiteit; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Breast Cancer Research Foundation; McGill University; Univerzita Karlova v Praze; Clalit Health Services; Deutsches Krebsforschungszentrum; Peter MacCallum Cancer Centre; Helsingin ja Uudenmaan Sairaanhoitopiiri; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancer Center, University of Kansas; Cancerfonden; Canadian Breast Cancer Research Alliance; European Commission; Istituto Oncologico Veneto; Royal Marsden NHS Foundation Trust; Helsingin Yliopisto; Memorial Sloan-Kettering Cancer Center; Génome Québec; Dr. Ralph and Marian Falk Medical Research Trust; Kansas Bioscience Authority; European Social Fund; University of Chicago; Instituto de Salud Carlos III; Ohio State University; Cancer Australia; U.S. Department of Defense; Cancer Research UK; University of Southern California","keywords":"Breast cancer; Surgical oncology; Medicine; Allele; Oncology; Mutation; BRCA2 Protein; Internal medicine; Genetics; Cancer; Germline mutation; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001247194,0.000223992,0.0003984175,0.0002165581,0.0001691831,0.00003134497,0.0003082047,0.0002161863,0.0001778327],"category_scores_gemma":[0.0000743344,0.0002054214,0.00007231495,0.0006439707,0.0007043837,0.00002614861,0.0001519503,0.0003535228,9.404089e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000592982,"about_ca_system_score_gemma":0.001352787,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.08073599,"about_ca_topic_score_gemma":0.1645489,"domain_scores_codex":[0.997233,0.000564207,0.0004529545,0.0006290728,0.0006246952,0.0004960372],"domain_scores_gemma":[0.9977117,0.0001164973,0.0003145626,0.0005172573,0.001195667,0.0001443253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007935866,0.0001610497,0.9232029,0.0001536393,0.0002987517,0.000001073996,0.0006848014,0.00388055,0.03959019,0.0000546979,0.000607754,0.03057096],"study_design_scores_gemma":[0.001400427,0.0001114216,0.9823248,0.0001440273,0.00006153496,0.00003302854,0.000522643,0.0004211596,0.01443809,0.0001259418,0.0001909855,0.000225881],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893567,0.001476215,0.00005590069,0.001561899,0.00008083478,0.0004601323,0.006842175,0.00000982363,0.000156316],"genre_scores_gemma":[0.9975342,0.00155255,0.0001174124,0.0000404553,0.0002235284,0.0002937794,0.0001154443,0.00004573388,0.00007690456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0838129,"threshold_uncertainty_score":0.9253855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042418714421266,"score_gpt":0.3444474156572364,"score_spread":0.3240232285130237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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