{"id":"W2029507468","doi":"10.1021/bi7015525","title":"Mutational Analysis of the Active Site Flap (20s Loop) of Mandelate Racemase","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Stereochemistry; Racemization; Chemistry; Active site; Steric effects; Mutant; Substrate (aquarium); Pseudomonas putida; Loop (graph theory); Enzyme kinetics; Oxyanion hole; Catalysis; Crystallography; Enzyme; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827664,0.00006211193,0.0001213762,0.00003787013,0.00003625439,0.00000466141,0.0001007551,0.00006913426,0.0005173627],"category_scores_gemma":[0.0000566699,0.00004415217,0.000102456,0.000351972,0.00009770123,0.00003266958,0.00003356118,0.00004631971,0.000004143385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002155002,"about_ca_system_score_gemma":0.00003568019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002653913,"about_ca_topic_score_gemma":0.00001372079,"domain_scores_codex":[0.9993808,0.00001090542,0.0001872085,0.0001329881,0.0001965614,0.00009154288],"domain_scores_gemma":[0.9994308,0.00004954631,0.0001872485,0.0002065133,0.00009918921,0.00002664103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006469285,0.0000152423,0.001580119,0.00002039645,0.00006839266,9.802043e-7,0.0001234018,0.0001543325,0.9976623,0.00003268052,0.000101211,0.0001762538],"study_design_scores_gemma":[0.0001203447,0.000006484998,0.03094104,0.00000715936,0.0002100071,0.000002141209,0.00009067864,0.00009547223,0.968396,0.00006048212,0.00002542964,0.00004477515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973573,0.00004779009,0.0005759645,0.00002137285,0.0001109767,0.00003265917,0.00008146979,0.000007199417,0.001765267],"genre_scores_gemma":[0.9989972,0.000001142906,0.000259746,0.00002302142,0.00004636166,9.077633e-7,0.00003124775,0.000003065764,0.0006373624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02936092,"threshold_uncertainty_score":0.5664759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00479527231910551,"score_gpt":0.2307875793243217,"score_spread":0.2259923070052162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}